(2R,4S,5R)-5-(azidomethyl)-4-(benzyloxy)tetrahydrofuran-2-carboxylic acid

Base Information

Chemical Name:(2R,4S,5R)-5-(azidomethyl)-4-(benzyloxy)tetrahydrofuran-2-carboxylic acid
CAS No.:1190850-84-0
Molecular Formula:C₁₃H₁₅N₃O₄
Molecular Weight:277.28
Hs Code.:

Synonyms:

Suppliers and Price of (2R,4S,5R)-5-(azidomethyl)-4-(benzyloxy)tetrahydrofuran-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,4S,5R)-5-(azidomethyl)-4-(benzyloxy)tetrahydrofuran-2-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,4S,5R)-5-(azidomethyl)-4-(benzyloxy)tetrahydrofuran-2-carboxylic acid

There total 10 articles about (2R,4S,5R)-5-(azidomethyl)-4-(benzyloxy)tetrahydrofuran-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂HF₃O₂*C₁₃H₁₇NO₄

: 1190850-84-0
(2R,4S,5R)-5-(azidomethyl)-4-(benzyloxy)tetrahydrofuran-2-carboxylic acid

Guidance literature:: With triflic azide; potassium carbonate; copper(II) sulfate; In methanol; dichloromethane; water; for 16h;
DOI:10.1002/ejoc.200900460

Reference yield:

: 22860-23-7
(2R,3S)-2-[(acetyloxy)methyl]-6-oxo-3,6-dihydro-2H-pyran-3,5-diyl diacetate

: 1190850-84-0
(2R,4S,5R)-5-(azidomethyl)-4-(benzyloxy)tetrahydrofuran-2-carboxylic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 16 h / 48754.9 Torr

2.1: sodium methylate / methanol / 3 h

2.2: Dowex H⁺ / 16 h / 50 °C / pH 5

3.1: sulfuric acid; magnesium sulfate

4.1: pyridine / toluene / 1 h / 0 °C

5.1: trifluoroacetic acid; water / 3 h / Heating

6.1: Ambelite IR₁₂₀ H⁺ / 3 h

7.1: triethylamine; dmap / toluene; dichloromethane

8.1: sodium azide / N,N-dimethyl-formamide / 16 h / 85 °C

9.1: water / tetrahydrofuran / 3 h

10.1: sodium hydride / N,N-dimethyl-formamide / 0 °C

10.2: 3 h / 0 °C

With pyridine; dmap; sodium azide; sulfuric acid; palladium 10% on activated carbon; water; hydrogen; sodium methylate; sodium hydride; magnesium sulfate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1002/hlca.201200497

Reference yield:

: 115944-84-8
1,2-dideoxy-1β-(methoxycarbonyl)-D-erythro-pentofuranose

: 1190850-84-0
(2R,4S,5R)-5-(azidomethyl)-4-(benzyloxy)tetrahydrofuran-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; dmap / toluene; dichloromethane

2.1: sodium azide / N,N-dimethyl-formamide / 16 h / 85 °C

3.1: water / tetrahydrofuran / 3 h

4.1: sodium hydride / N,N-dimethyl-formamide / 0 °C

4.2: 3 h / 0 °C

With dmap; sodium azide; water; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/hlca.201200497