(S)-2-(benzylamino)-1-(2,8-bis(trifluoromethyl)quinolin-4-yl)ethanol

Base Information

Chemical Name:(S)-2-(benzylamino)-1-(2,8-bis(trifluoromethyl)quinolin-4-yl)ethanol
CAS No.:1292282-25-7
Molecular Formula:C₂₀H₁₆F₆N₂O
Molecular Weight:414.35
Hs Code.:

Synonyms:

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Chemical Property of (S)-2-(benzylamino)-1-(2,8-bis(trifluoromethyl)quinolin-4-yl)ethanol

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Technology Process of (S)-2-(benzylamino)-1-(2,8-bis(trifluoromethyl)quinolin-4-yl)ethanol

There total 9 articles about (S)-2-(benzylamino)-1-(2,8-bis(trifluoromethyl)quinolin-4-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1292282-25-7
(S)-2-(benzylamino)-1-(2,8-bis(trifluoromethyl)quinolin-4-yl)ethanol

Guidance literature:

Reference yield:

: 35853-41-9
2,8-bis(trifluoromethyl)quinolin-4-ol

: 1292282-25-7
(S)-2-(benzylamino)-1-(2,8-bis(trifluoromethyl)quinolin-4-yl)ethanol

Guidance literature:: Multi-step reaction with 7 steps

1: phosphorus(V) oxybromide / 6 h / 150 °C / Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; tetrabutylammomium bromide; potassium carbonate / acetonitrile / 4 h / 90 °C / Inert atmosphere; Sealed tube

3: potassium osmate(VI) dihydrate; AD-mix α / water; tert-butyl alcohol / 0 °C

4: toluene-4-sulfonic acid / dichloromethane / 4 h / 20 °C / Inert atmosphere

5: chloro-trimethyl-silane / dichloromethane / 0 - 20 °C / Inert atmosphere

6: potassium carbonate / methanol / 5 h

7: isopropyl alcohol / 24 h / 90 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium osmate(VI) dihydrate; chloro-trimethyl-silane; AD-mix α; tetrabutylammomium bromide; potassium carbonate; toluene-4-sulfonic acid; phosphorus(V) oxybromide; In methanol; dichloromethane; water; isopropyl alcohol; acetonitrile; tert-butyl alcohol; 2: Stille coupling / 3: Sharpless dihydroxylation;
DOI:10.1016/j.tetasy.2011.01.003

Reference yield:

: 35853-45-3
(2,8-bis-trifluoromethyl)-4-bromoquinoline

: 1292282-25-7
(S)-2-(benzylamino)-1-(2,8-bis(trifluoromethyl)quinolin-4-yl)ethanol

Guidance literature:: Multi-step reaction with 6 steps

1: bis-triphenylphosphine-palladium(II) chloride; tetrabutylammomium bromide; potassium carbonate / acetonitrile / 4 h / 90 °C / Inert atmosphere; Sealed tube

2: potassium osmate(VI) dihydrate; AD-mix α / water; tert-butyl alcohol / 0 °C

3: toluene-4-sulfonic acid / dichloromethane / 4 h / 20 °C / Inert atmosphere

4: chloro-trimethyl-silane / dichloromethane / 0 - 20 °C / Inert atmosphere

5: potassium carbonate / methanol / 5 h

6: isopropyl alcohol / 24 h / 90 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium osmate(VI) dihydrate; chloro-trimethyl-silane; AD-mix α; tetrabutylammomium bromide; potassium carbonate; toluene-4-sulfonic acid; In methanol; dichloromethane; water; isopropyl alcohol; acetonitrile; tert-butyl alcohol; 1: Stille coupling / 2: Sharpless dihydroxylation;
DOI:10.1016/j.tetasy.2011.01.003