C₂₆H₂₆ClNO₃S

Base Information

• Chemical Name: C₂₆H₂₆ClNO₃S
• CAS No.: 1627704-46-4
• Molecular Formula: C₂₆H₂₆ClNO₃S
• Molecular Weight: 468.016
• Mol file: 1627704-46-4.mol

Synonyms:

Chemical Property of C₂₆H₂₆ClNO₃S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₂₆ClNO₃S

There total 6 articles about C₂₆H₂₆ClNO₃S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-bromo-phenylsulfanyl)-piperidine-1-carboxylic acid tert-butyl ester (1027143-39-0) → C26H26ClNO3S (1627704-46-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 90 °C

2.1: hydrogenchloride

3.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 120 °C

4.1: sodium periodate / methanol; water / Reflux

4.2: Chiral AD column / Resolution of racemate

With hydrogenchloride; sodium periodate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; 1,2-dimethoxyethane; water; dimethyl sulfoxide; 1.1: |Suzuki Coupling;

DOI:10.1016/j.bmcl.2014.05.036

Reference yield:

C22H26ClNO2S (1616557-98-2) → C26H26ClNO3S (1627704-46-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride

2.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 120 °C

3.1: sodium periodate / methanol; water / Reflux

3.2: Chiral AD column / Resolution of racemate

With hydrogenchloride; sodium periodate; N-ethyl-N,N-diisopropylamine; In methanol; water; dimethyl sulfoxide;

DOI:10.1016/j.bmcl.2014.05.036

Reference yield:

o-bromothiophenol (6320-02-1) → C26H26ClNO3S (1627704-46-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 85 °C

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 90 °C

3.1: hydrogenchloride

4.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 120 °C

5.1: sodium periodate / methanol; water / Reflux

5.2: Chiral AD column / Resolution of racemate

With hydrogenchloride; sodium periodate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; 1,2-dimethoxyethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 2.1: |Suzuki Coupling;

DOI:10.1016/j.bmcl.2014.05.036

upstream raw materials:

tert-butyl 4-bromo-1-piperidinecarboxylate

o-bromothiophenol

4-(2-bromo-phenylsulfanyl)-piperidine-1-carboxylic acid tert-butyl ester

C₂₂H₂₆ClNO₂S

Downstream raw materials:

C₄₅H₄₆ClF₃N₄O₇S₄

C₂₄H₂₂ClNO₃S