(E)-3-Dimethylamino-2-((3aS,6R,6aR)-2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-acrylonitrile

Base Information

• Chemical Name: (E)-3-Dimethylamino-2-((3aS,6R,6aR)-2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-acrylonitrile
• CAS No.: 60526-02-5
• Molecular Formula: C₃₂H₃₄N₂O₄
• Molecular Weight: 510.633
• Mol file: 60526-02-5.mol

Synonyms:

Chemical Property of (E)-3-Dimethylamino-2-((3aS,6R,6aR)-2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-acrylonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-Dimethylamino-2-((3aS,6R,6aR)-2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-acrylonitrile

There total 1 articles about (E)-3-Dimethylamino-2-((3aS,6R,6aR)-2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-(dimethylamino-methylene)-O4,O5-isopropylidene-O7-trityl-D-altro-3,6-anhydro-2-deoxy-heptononitrile (60526-02-5)

Guidance literature:

2',3'-O-Isopropyliden-5-O-trityl-α-D-ribofuranosylacetonitril, Bis(dimethylamino)-tert.butoxymethan;

DOI:10.1021/jo00393a019

Reference yield:

(E)-3-Dimethylamino-2-((3aS,6R,6aR)-2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-acrylonitrile (60526-02-5,60526-03-6,83289-74-1,84710-19-0,84710-20-3) → 2-Formyl-2-(2,3-O-isopropyliden-5-O-trityl-D-ribofuranosyl)-acetonitril (74458-09-6,74458-10-9,77715-48-1,83348-75-8,84710-21-4,84710-22-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; water; at 20 ℃; for 5h;

DOI:10.1016/S0040-4039(00)84108-8

Reference yield:

2-(dimethylamino-methylene)-O4,O5-isopropylidene-O7-trityl-D-altro-3,6-anhydro-2-deoxy-heptononitrile (60526-02-5) → 2-amino-8-(O2,O3-isopropylidene-O5-trityl-β-D-ribofuranosyl)-3H-pyrazolo[1,5-a][1,3,5]triazin-4-one (71774-73-7)

Guidance literature:

Multi-step reaction with 3 steps

1: (i) N₂H₄*HCl, aq. MeOH, (ii) MeCN

2: CH₂Cl₂; diethyl ether

3: aq. NaOH / dimethylformamide

With sodium hydroxide; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo00393a019

Downstream raw materials:

(1R)-D-1-(3-amino-1⁽²⁾H-pyrazol-4-yl)-O²,O³-isopropylidene-O⁵-trityl-1,4-anhydro-ribitol

4-(β-2,3-O-isopropylidene-5-O-tritylribofuranosyl)-3-aminopyrazole

2-amino-8-(O²,O³-isopropylidene-O⁵-trityl-β-D-ribofuranosyl)-3H-pyrazolo[1,5-a][1,3,5]triazin-4-one

2-Formyl-2-(2,3-O-isopropyliden-5-O-trityl-D-ribofuranosyl)-acetonitril