4-[2-Oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-11-yl)-ethyl]-piperazine-1-carbothioic acid phenylamide

Base Information

• Chemical Name: 4-[2-Oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-11-yl)-ethyl]-piperazine-1-carbothioic acid phenylamide
• CAS No.: 133727-64-7
• Molecular Formula: C₂₅H₂₄N₆O₂S
• Molecular Weight: 472.571
• Mol file: 133727-64-7.mol

Synonyms:

Chemical Property of 4-[2-Oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-11-yl)-ethyl]-piperazine-1-carbothioic acid phenylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[2-Oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-11-yl)-ethyl]-piperazine-1-carbothioic acid phenylamide

There total 3 articles about 4-[2-Oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-11-yl)-ethyl]-piperazine-1-carbothioic acid phenylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pirenzepine dihydrochloride (29868-97-1,93173-05-8) → 4-[2-Oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-11-yl)-ethyl]-piperazine-1-carbothioic acid phenylamide (133727-64-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) α-chloroethyl chloroformate, N,N,N-diisopropylethylamine, 2.) 1 M HCl in ether / 1.) chloroform, reflux, 1 h, 2.) methanol, reflux, 3 h

2: CHCl₃

With hydrogenchloride; carbonochloridic acid 1-chloro-ethyl ester; N-ethyl-N,N-diisopropylamine; In chloroform;

DOI:10.1021/jm00111a032

Reference yield:

5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one (885-70-1) → 4-[2-Oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-11-yl)-ethyl]-piperazine-1-carbothioic acid phenylamide (133727-64-7)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dioxane / 5 h / Heating

2: dioxane / 1 h / Heating

3: CHCl₃

With triethylamine; In 1,4-dioxane; chloroform;

DOI:10.1021/jm00111a032

Reference yield:

11-(chloroacetyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one (28797-48-0) → 4-[2-Oxo-2-(6-oxo-5,6-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-11-yl)-ethyl]-piperazine-1-carbothioic acid phenylamide (133727-64-7)

Guidance literature:

Multi-step reaction with 2 steps

1: dioxane / 1 h / Heating

2: CHCl₃

In 1,4-dioxane; chloroform;

DOI:10.1021/jm00111a032

upstream raw materials:

pirenzepine dihydrochloride

11-(chloroacetyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one

Refernces