C₁₂H₁₄F₂NO₂P

Base Information

Chemical Name:C₁₂H₁₄F₂NO₂P
CAS No.:1001098-14-1
Molecular Formula:C₁₂H₁₄F₂NO₂P
Molecular Weight:273.219
Hs Code.:

C<sub>12</sub>H<sub>14</sub>F<sub>2</sub>NO<sub>2</sub>P

Synonyms:

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Chemical Property of C₁₂H₁₄F₂NO₂P

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Technology Process of C₁₂H₁₄F₂NO₂P

There total 6 articles about C₁₂H₁₄F₂NO₂P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1001096-02-1
(1-benzyloxycarbonylamino-2-vinyl-cyclopropyl)-(2,6-difluoro-benzyl)-phosphinic acid ethyl ester

: 1001098-14-1
C₁₂H₁₄F₂NO₂P

Guidance literature:: With trimethylsilyl iodide; In acetonitrile; at 0 - 20 ℃;
DOI:10.1016/j.tetlet.2012.02.111

Reference yield:

: 1001095-46-0
C₁₅H₂₀NO₄P

: 1001098-14-1
C₁₂H₁₄F₂NO₂P

Guidance literature:: Multi-step reaction with 2 steps

1.1: chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

1.2: 12.05 h / 40 °C / Inert atmosphere

2.1: trimethylsilyl iodide / acetonitrile / 0 - 20 °C

With chloro-trimethyl-silane; trimethylsilyl iodide; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;
DOI:10.1016/j.tetlet.2012.02.111

Reference yield:

: 877068-78-5
C₁₇H₂₄NO₅P

: 1001098-14-1
C₁₂H₁₄F₂NO₂P

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine; sodium iodide / 5 h / Reflux

2.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 2 h / 0 °C

3.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 2 h / -78 - 20 °C

3.2: Cooling with ice

4.1: chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

4.2: 12.05 h / 40 °C / Inert atmosphere

5.1: trimethylsilyl iodide / acetonitrile / 0 - 20 °C

With pyridine; chloro-trimethyl-silane; oxalyl dichloride; trimethylsilyl iodide; lithium tri-t-butoxyaluminum hydride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; sodium iodide; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;
DOI:10.1016/j.tetlet.2012.02.111