3,6-dihydro-4-methyl-2-thioxo-6-<2-(trifluoromethyl)phenyl>-1,5(2H)-pyrimidinedicarboxylic acid 5-ethyl 1-<1-(phenylmethyl)-4-piperidinyl> diester monohydrochloride

Base Information

Chemical Name:3,6-dihydro-4-methyl-2-thioxo-6-<2-(trifluoromethyl)phenyl>-1,5(2H)-pyrimidinedicarboxylic acid 5-ethyl 1-<1-(phenylmethyl)-4-piperidinyl> diester monohydrochloride
CAS No.:108931-33-5
Molecular Formula:C₂₈H₃₀F₃N₃O₄S*ClH
Molecular Weight:598.086
Hs Code.:

3,6-dihydro-4-methyl-2-thioxo-6-<2-(trifluoromethyl)phenyl>-1,5(2H)-pyrimidinedicarboxylic acid 5-ethyl 1-<1-(phenylmethyl)-4-piperidinyl> diester monohydrochloride

Synonyms:

Suppliers and Price of 3,6-dihydro-4-methyl-2-thioxo-6-<2-(trifluoromethyl)phenyl>-1,5(2H)-pyrimidinedicarboxylic acid 5-ethyl 1-<1-(phenylmethyl)-4-piperidinyl> diester monohydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3,6-dihydro-4-methyl-2-thioxo-6-<2-(trifluoromethyl)phenyl>-1,5(2H)-pyrimidinedicarboxylic acid 5-ethyl 1-<1-(phenylmethyl)-4-piperidinyl> diester monohydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3,6-dihydro-4-methyl-2-thioxo-6-<2-(trifluoromethyl)phenyl>-1,5(2H)-pyrimidinedicarboxylic acid 5-ethyl 1-<1-(phenylmethyl)-4-piperidinyl> diester monohydrochloride

There total 6 articles about 3,6-dihydro-4-methyl-2-thioxo-6-<2-(trifluoromethyl)phenyl>-1,5(2H)-pyrimidinedicarboxylic acid 5-ethyl 1-<1-(phenylmethyl)-4-piperidinyl> diester monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108932-21-4
4-methyl-2-<<(4-methoxyphenyl)methyl>thio>-6-<2-(trifluoromethyl)phenyl>-1,5(6H)-pyrimidinedicarboxylic acid 5-ethyl 1-<1-(phenylmethyl)-4-piperidinyl> diester

: 108931-33-5
3,6-dihydro-4-methyl-2-thioxo-6-<2-(trifluoromethyl)phenyl>-1,5(2H)-pyrimidinedicarboxylic acid 5-ethyl 1-<1-(phenylmethyl)-4-piperidinyl> diester monohydrochloride

Guidance literature:: With trifluoroacetic acid; ethanethiol; In dichloromethane; for 6h; Ambient temperature;
DOI:10.1021/jo00286a020

Reference yield:

: 114957-75-4
2-[[2-(trifluoromethyl)phenyl]methylene]-3-oxobutanoic acid,ethyl ester

: 108931-33-5
3,6-dihydro-4-methyl-2-thioxo-6-<2-(trifluoromethyl)phenyl>-1,5(2H)-pyrimidinedicarboxylic acid 5-ethyl 1-<1-(phenylmethyl)-4-piperidinyl> diester monohydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 64 percent / sodium acetate / dimethylformamide / 4 h / 70 °C

2: pyridine / acetonitrile; toluene / 6 h / Ambient temperature

3: 6.4 g / acetonitrile / 16 h / Ambient temperature

4: 3.7 g / trifluoroacetic acid, ethanethiol / CH₂Cl₂ / 6 h / Ambient temperature

With pyridine; sodium acetate; trifluoroacetic acid; ethanethiol; In dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jo00286a020

Reference yield:

: 1-Chlorocarbonyl-2-(4-methoxy-benzylsulfanyl)-4-methyl-6-(2-trifluoromethyl-phenyl)-1,6-dihydro-pyrimidine-5-carboxylic acid ethyl ester

: 108931-33-5
3,6-dihydro-4-methyl-2-thioxo-6-<2-(trifluoromethyl)phenyl>-1,5(2H)-pyrimidinedicarboxylic acid 5-ethyl 1-<1-(phenylmethyl)-4-piperidinyl> diester monohydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 6.4 g / acetonitrile / 16 h / Ambient temperature

2: 3.7 g / trifluoroacetic acid, ethanethiol / CH₂Cl₂ / 6 h / Ambient temperature

With trifluoroacetic acid; ethanethiol; In dichloromethane; acetonitrile;
DOI:10.1021/jo00286a020