2-(4-broMophenyl)Malonyl dichloride

Base Information

• Chemical Name: 2-(4-broMophenyl)Malonyl dichloride
• CAS No.: 68823-01-8
• Molecular Formula: C₉H₅BrCl₂O₂
• Molecular Weight: 295.947
• Mol file: 68823-01-8.mol

Synonyms:

Chemical Property of 2-(4-broMophenyl)Malonyl dichloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-broMophenyl)Malonyl dichloride

There total 3 articles about 2-(4-broMophenyl)Malonyl dichloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-bromophenyl)propanedioic acid (773873-10-2) → (4-bromo-phenyl)-malonyl dichloride (68823-01-8)

Guidance literature:

With phosphorus pentachloride; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.organomet.7b00206

Reference yield:

1,4-bromoiodobenzene (589-87-7) → (4-bromo-phenyl)-malonyl dichloride (68823-01-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 2-Picolinic acid; caesium carbonate; copper(l) iodide / 1,4-dioxane / 65 h / 94 °C / Inert atmosphere; Schlenk technique

2: sodium hydroxide / methanol; water / 2 h / 20 °C / Inert atmosphere; Schlenk technique

3: phosphorus pentachloride / dichloromethane / 2 h / 20 °C / Inert atmosphere; Schlenk technique

With 2-Picolinic acid; copper(l) iodide; phosphorus pentachloride; caesium carbonate; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water;

DOI:10.1021/acs.organomet.7b00206

Reference yield:

2-(4-bromophenyl)malonic acid diethyl ester (93139-85-6) → (4-bromo-phenyl)-malonyl dichloride (68823-01-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / methanol; water / 2 h / 20 °C / Inert atmosphere; Schlenk technique

2: phosphorus pentachloride / dichloromethane / 2 h / 20 °C / Inert atmosphere; Schlenk technique

With phosphorus pentachloride; sodium hydroxide; In methanol; dichloromethane; water;

DOI:10.1021/acs.organomet.7b00206

upstream raw materials:

1,4-bromoiodobenzene

2-(4-bromophenyl)malonic acid diethyl ester

2-(4-bromophenyl)propanedioic acid

Downstream raw materials:

5-(4-bromo-phenyl)-2,3-dimethyl-4,6-dioxo-5,6-dihydro-4H-[1,3]oxazinium betaine

Refernces