methyl (3S,5S,6S)-3-benzyloxycarbonylamino-6-<(E,E)-hexa-2,4-dienoylamino>-5-hydroxyheptanoate

Base Information

Chemical Name:methyl (3S,5S,6S)-3-benzyloxycarbonylamino-6-<(E,E)-hexa-2,4-dienoylamino>-5-hydroxyheptanoate
CAS No.:119961-34-1
Molecular Formula:C₂₂H₃₀N₂O₆
Molecular Weight:418.49
Hs Code.:

Synonyms:

Suppliers and Price of methyl (3S,5S,6S)-3-benzyloxycarbonylamino-6-<(E,E)-hexa-2,4-dienoylamino>-5-hydroxyheptanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl (3S,5S,6S)-3-benzyloxycarbonylamino-6-<(E,E)-hexa-2,4-dienoylamino>-5-hydroxyheptanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl (3S,5S,6S)-3-benzyloxycarbonylamino-6-<(E,E)-hexa-2,4-dienoylamino>-5-hydroxyheptanoate

There total 19 articles about methyl (3S,5S,6S)-3-benzyloxycarbonylamino-6-<(E,E)-hexa-2,4-dienoylamino>-5-hydroxyheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 119960-20-2
(6S)-6-<(1S)-1-(tert-butoxycarbonylamino)ethyl>-5,6-dihydro-2H-pyran-2,4(3H)-dione

: 119961-34-1,120053-46-5,138124-21-7
methyl (3S,5S,6S)-3-benzyloxycarbonylamino-6-<(E,E)-hexa-2,4-dienoylamino>-5-hydroxyheptanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 72.2 percent / ammonium acetate / molecular sieves 4 Angstroem / CHCl₃ / 3 h / Heating

2: 1.) H₂, H₃PO₄, 2.) NaHCO₃ / 1.) 5percent Pt/C / 1.) THF, r.t., 2.) water, THF, r.t., 3 h

3: diisopropylethylamine / 16 h / Ambient temperature; further base: MeONa

4: 1.) HCl/MeOH, 2.) pyridine / 1.) 5 deg C, 2.) CH₂Cl₂, 5 deg C, 1-2 h

With pyridine; ammonium acetate; hydrogenchloride; methanol; phosphoric acid; hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; platinum on activated charcoal; 4 A molecular sieve; In chloroform;

Reference yield:

: 101669-78-7
methyl (S)-4-[(tert-butoxycarbonyl)amino]-3-oxopentanoate

: 119961-34-1,120053-46-5,138124-21-7
methyl (3R,5R,6S)-3-benzyloxycarbonylamino-6-<(E,E)-hexa-2,4-dienoylamino>-5-hydroxyheptanoate

Guidance literature:: Multi-step reaction with 8 steps

1: 87 percent / H₂O; ethanol / 120 h / Ambient temperature; dry yeast / saccharose

2: 96.1 percent / aq. NaOH / dioxane; methanol; H₂O / 6 h / Ambient temperature

3: 59.3 percent / N,N'-carbonyldiimidazole (CDI) / tetrahydrofuran / 18 h / Ambient temperature

4: 99.9 percent / aq. NaOH / tetrahydrofuran / 1.5 h / Ambient temperature

5: hydroxylamine hydrochloride, pyridine / methanol / 1.) 5 deg C, 1 h, 2.) r.t., 3 h

6: 1.) H₂, H₃PO₄ - P₂O₅, 2.) NaHCO₃ / 1.) 5percent Pt/C / 1.) THF, r.t., 2.) water, THF, r.t., 3 h

7: diisopropylethylamine / 16 h / Ambient temperature; further base: MeONa

8: 1.) HCl/MeOH, 2.) pyridine / 1.)5 deg C, 2.) CH₂Cl₂, 5 deg C, 1-2 h

With pyridine; hydrogenchloride; methanol; sodium hydroxide; phosphoric acid; hydroxylamine hydrochloride; hydrogen; phosphorus pentoxide; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; platinum on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water;

Reference yield:

: 119960-09-7
(3R,4S)-4-(tert-butoxycarbonylamino)-3-hydroxypentanoic acid

: 119961-34-1,120053-46-5,138124-21-7
methyl (3R,5R,6S)-3-benzyloxycarbonylamino-6-<(E,E)-hexa-2,4-dienoylamino>-5-hydroxyheptanoate

Guidance literature:: Multi-step reaction with 6 steps

1: 59.3 percent / N,N'-carbonyldiimidazole (CDI) / tetrahydrofuran / 18 h / Ambient temperature

2: 99.9 percent / aq. NaOH / tetrahydrofuran / 1.5 h / Ambient temperature

3: hydroxylamine hydrochloride, pyridine / methanol / 1.) 5 deg C, 1 h, 2.) r.t., 3 h

4: 1.) H₂, H₃PO₄ - P₂O₅, 2.) NaHCO₃ / 1.) 5percent Pt/C / 1.) THF, r.t., 2.) water, THF, r.t., 3 h

5: diisopropylethylamine / 16 h / Ambient temperature; further base: MeONa

6: 1.) HCl/MeOH, 2.) pyridine / 1.)5 deg C, 2.) CH₂Cl₂, 5 deg C, 1-2 h

With pyridine; hydrogenchloride; methanol; sodium hydroxide; phosphoric acid; hydroxylamine hydrochloride; hydrogen; phosphorus pentoxide; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; platinum on activated charcoal; In tetrahydrofuran; methanol;