(3R,4R)-4-{(S)-4-(tert-Butyl-dimethyl-silanyloxy)-1-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-butyl}-3,4-dimethyl-cyclohexanone

Base Information

• Chemical Name: (3R,4R)-4-{(S)-4-(tert-Butyl-dimethyl-silanyloxy)-1-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-butyl}-3,4-dimethyl-cyclohexanone
• CAS No.: 138100-33-1
• Molecular Formula: C₂₆H₅₄O₃Si₂
• Molecular Weight: 470.884
• Mol file: 138100-33-1.mol

Synonyms:

Chemical Property of (3R,4R)-4-{(S)-4-(tert-Butyl-dimethyl-silanyloxy)-1-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-butyl}-3,4-dimethyl-cyclohexanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,4R)-4-{(S)-4-(tert-Butyl-dimethyl-silanyloxy)-1-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-butyl}-3,4-dimethyl-cyclohexanone

There total 1 articles about (3R,4R)-4-{(S)-4-(tert-Butyl-dimethyl-silanyloxy)-1-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-butyl}-3,4-dimethyl-cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(S)-4-{(R)-4-(tert-Butyl-dimethyl-silanyloxy)-1-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-butyl}-4-methyl-cyclohex-2-enone (138100-32-0,138232-22-1) + C2H6Cu(1-)*I(1-)*Mg(2+) → (3R,4R)-4-{(S)-4-(tert-Butyl-dimethyl-silanyloxy)-1-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-butyl}-3,4-dimethyl-cyclohexanone (138100-33-1,138232-23-2)

Guidance literature:

In diethyl ether; at 0 ℃;

DOI:10.1016/S0040-4039(00)79435-4

Reference yield: 73.0%

(3R,4R)-4-{(S)-4-(tert-Butyl-dimethyl-silanyloxy)-1-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-butyl}-3,4-dimethyl-cyclohexanone (138100-33-1,138232-23-2) + carbonic acid dimethyl ester (616-38-6) → (4R,5R)-5-{(S)-4-(tert-Butyl-dimethyl-silanyloxy)-1-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-butyl}-2-hydroxy-4,5-dimethyl-cyclohex-1-enecarboxylic acid methyl ester (138100-34-2,138232-24-3)

Guidance literature:

With sodium hydride; In tetrahydrofuran; Heating;

DOI:10.1016/S0040-4039(00)79435-4

Reference yield:

(3R,4R)-4-{(S)-4-(tert-Butyl-dimethyl-silanyloxy)-1-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-butyl}-3,4-dimethyl-cyclohexanone (138100-33-1,138232-23-2) → (3S,4R)-3-{(S)-4-(tert-Butyl-dimethyl-silanyloxy)-1-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-butyl}-3,4-dimethyl-6-oxo-cyclohex-1-enecarboxylic acid methyl ester (138100-35-3,138232-25-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent / NaH / tetrahydrofuran / Heating

2: pyridine / CH₂Cl₂

3: H₂O₂

With pyridine; dihydrogen peroxide; sodium hydride; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4039(00)79435-4

upstream raw materials:

(S)-4-{(R)-4-(tert-Butyl-dimethyl-silanyloxy)-1-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-butyl}-4-methyl-cyclohex-2-enone

Downstream raw materials:

(4R,5R)-5-{(S)-4-(tert-Butyl-dimethyl-silanyloxy)-1-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-butyl}-2-hydroxy-4,5-dimethyl-cyclohex-1-enecarboxylic acid methyl ester

(3S,4R)-3-{(S)-4-(tert-Butyl-dimethyl-silanyloxy)-1-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-butyl}-3,4-dimethyl-6-oxo-cyclohex-1-enecarboxylic acid methyl ester