Technology Process of 4-benzyl-7-bromo-3-hexyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one
There total 7 articles about 4-benzyl-7-bromo-3-hexyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: dichloromethane / 2 h / 20 °C / Molecular sieve
2: water; trimethylphosphane / tetrahydrofuran; toluene / 0 - 20 °C
3: 5,5-dimethyl-1,3-cyclohexadiene / Reflux
With
water; trimethylphosphane;
In
tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; toluene;
2: Staudinger reaction;
DOI:10.1021/jo2015054
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium sulfate / dichloromethane / 3 h / 20 °C
2: sodium cyanoborohydride; acetic acid / methanol / 0 - 20 °C
3: dichloromethane / 2 h / 20 °C / Molecular sieve
4: water; trimethylphosphane / tetrahydrofuran; toluene / 0 - 20 °C
5: 5,5-dimethyl-1,3-cyclohexadiene / Reflux
With
water; sodium cyanoborohydride; acetic acid; sodium sulfate; trimethylphosphane;
In
tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; toluene;
4: Staudinger reaction;
DOI:10.1021/jo2015054
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium cyanoborohydride; acetic acid / methanol / 0 - 20 °C
2: dichloromethane / 2 h / 20 °C / Molecular sieve
3: water; trimethylphosphane / tetrahydrofuran; toluene / 0 - 20 °C
4: 5,5-dimethyl-1,3-cyclohexadiene / Reflux
With
water; sodium cyanoborohydride; acetic acid; trimethylphosphane;
In
tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; toluene;
3: Staudinger reaction;
DOI:10.1021/jo2015054
