Technology Process of 3,5-di-iodo-3'-<(6-methylpyridin-3-yl)methyl>-L-thyronine
There total 7 articles about 3,5-di-iodo-3'-<(6-methylpyridin-3-yl)methyl>-L-thyronine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 61 percent / butyl-lithium / hexane / THF, -90 deg C, -80 deg C, 10min , RT
2: pyridine / 100 °C
3: 64 percent / H2 / 10percent Pd/C / acetic acid; H2O / 1.5 h
4: 54 percent / methanesulphonyl chloride / pyridine / 1.17 h / Heating
5: H2 / 10percent Pd/C / acetic acid / 1 h / 2585.7 Torr
6: 1.) sulphuric acid, sodium nitrite, 2.) potassium iodide,iodine, urea / 1.) water, -10 deg C, 2.) chloroform, water, RT, 1-2 h
7: 68 percent / 48percent hydrobromic acid / acetic acid; H2O / 5 h / Heating
With
pyridine; n-butyllithium; sulfuric acid; hydrogen bromide; hydrogen; iodine; methanesulfonyl chloride; urea; potassium iodide; sodium nitrite;
palladium on activated charcoal;
In
pyridine; hexane; water; acetic acid;
DOI:10.1039/P19880003085
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 61 percent / butyl-lithium / hexane / THF, -90 deg C, -80 deg C, 10min , RT
2: pyridine / 100 °C
3: 64 percent / H2 / 10percent Pd/C / acetic acid; H2O / 1.5 h
4: 54 percent / methanesulphonyl chloride / pyridine / 1.17 h / Heating
5: H2 / 10percent Pd/C / acetic acid / 1 h / 2585.7 Torr
6: 1.) sulphuric acid, sodium nitrite, 2.) potassium iodide,iodine, urea / 1.) water, -10 deg C, 2.) chloroform, water, RT, 1-2 h
7: 68 percent / 48percent hydrobromic acid / acetic acid; H2O / 5 h / Heating
With
pyridine; n-butyllithium; sulfuric acid; hydrogen bromide; hydrogen; iodine; methanesulfonyl chloride; urea; potassium iodide; sodium nitrite;
palladium on activated charcoal;
In
pyridine; hexane; water; acetic acid;
DOI:10.1039/P19880003085
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 54 percent / methanesulphonyl chloride / pyridine / 1.17 h / Heating
2: H2 / 10percent Pd/C / acetic acid / 1 h / 2585.7 Torr
3: 1.) sulphuric acid, sodium nitrite, 2.) potassium iodide,iodine, urea / 1.) water, -10 deg C, 2.) chloroform, water, RT, 1-2 h
4: 68 percent / 48percent hydrobromic acid / acetic acid; H2O / 5 h / Heating
With
sulfuric acid; hydrogen bromide; hydrogen; iodine; methanesulfonyl chloride; urea; potassium iodide; sodium nitrite;
palladium on activated charcoal;
In
pyridine; water; acetic acid;
DOI:10.1039/P19880003085
