N-Benzyl-2-hydroxydesipramine

Base Information

• Chemical Name: N-Benzyl-2-hydroxydesipramine
• CAS No.: 134150-71-3
• Molecular Formula: C₂₅H₂₈N₂O
• Molecular Weight: 372.51
• Mol file: 134150-71-3.mol

Synonyms:

Chemical Property of N-Benzyl-2-hydroxydesipramine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Benzyl-2-hydroxydesipramine

There total 5 articles about N-Benzyl-2-hydroxydesipramine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formic acid 5-[3-(benzyl-methyl-amino)-propyl]-10,11-dihydro-5H-dibenzo[b,f]azepin-2-yl ester → N-Benzyl-2-hydroxydesipramine (134150-71-3)

Guidance literature:

With hydrogenchloride; In methanol; for 2h;

Reference yield:

N-Benzyldesipramine (3978-87-8) → N-Benzyl-2-hydroxydesipramine (134150-71-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 68 percent / POCl₃ / 4 h / 100 °C

2: m-CPBA; TFA / CH₂Cl₂ / 2 h / 5 - 20 °C

3: conc. HCl / methanol / 2 h

With hydrogenchloride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; trichlorophosphate; In methanol; dichloromethane; 1: Formylation / 2: Oxidation / 3: Hydrolysis;

Reference yield:

desipramine hydrochloride (58-28-6) → N-Benzyl-2-hydroxydesipramine (134150-71-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 48 percent / KOH; NaBH₃CN / methanol

2: 68 percent / POCl₃ / 4 h / 100 °C

3: m-CPBA; TFA / CH₂Cl₂ / 2 h / 5 - 20 °C

4: conc. HCl / methanol / 2 h

With hydrogenchloride; potassium hydroxide; sodium cyanoborohydride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; trichlorophosphate; In methanol; dichloromethane; 1: reductive amination; N-benzylation / 2: Formylation / 3: Oxidation / 4: Hydrolysis;

upstream raw materials:

N-Benzyldesipramine

desipramine hydrochloride

benzaldehyde

N-Benzyl-2-formyldesipramine

Downstream raw materials:

2-Hydroxydesipramine