4-benzyloxy-5-benzyloxymethyl-2-<(3'-tetrahydropyranyloxymethyl)pentylidene>tetrahydropyran

Base Information

• Chemical Name: 4-benzyloxy-5-benzyloxymethyl-2-<(3'-tetrahydropyranyloxymethyl)pentylidene>tetrahydropyran
• CAS No.: 113195-27-0
• Molecular Formula: C₃₁H₄₂O₅
• Molecular Weight: 494.671

Synonyms:

Chemical Property of 4-benzyloxy-5-benzyloxymethyl-2-<(3'-tetrahydropyranyloxymethyl)pentylidene>tetrahydropyran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-benzyloxy-5-benzyloxymethyl-2-<(3'-tetrahydropyranyloxymethyl)pentylidene>tetrahydropyran

There total 26 articles about 4-benzyloxy-5-benzyloxymethyl-2-<(3'-tetrahydropyranyloxymethyl)pentylidene>tetrahydropyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-oxopentanedioic acid dimethyl ester (1830-54-2) → 4-benzyloxy-5-benzyloxymethyl-2-<(3'-tetrahydropyranyloxymethyl)pentylidene>tetrahydropyran (113195-27-0,113299-79-9)

Guidance literature:

Multi-step reaction with 16 steps

1: NaBH₄ / methanol

2: p-TsOH*H₂O / diethyl ether

3: LiAlH₄ / diethyl ether

4: p-TsOH*H₂O / methanol

5: 98.3 g / p-TsOH*H₂O / acetone

6: 97 percent / pyridinium chlorochromate, MS (3 Angstroem) / CH₂Cl₂

7: 64 percent / p-TsOH*H₂O / CH₂Cl₂ / Heating

8: 72 percent / pyridinium dichromate, MS (3 Angstroem) / CH₂Cl₂

9: 1.) LDA, HMPA, 2.) HMPA / 1.) hexane/THF, -76 -72 deg C, 13 min, then -35 deg C, 2.) -78 deg C, 15 min

10: 11 percent / sucrose, phosphate buffer, baker's yeast, 0.2 percent Triton -100 aq. / 1 h / 30 °C

11: p-TsOH*H₂O / ethanol; H₂O / 168 h / Ambient temperature

12: 4-(N,N-dimethylamino)pyridine / pyridine

13: 97 percent / LAH / diethyl ether

14: 80 percent / NaH (60 percent), n-Bu₄N⁽¹⁺⁾*I^(1-) / paraffin; tetrahydrofuran / 1 h / Heating

15: acetonitrile / 1 h / Heating

16: 1.) HMPA, n-BuLi / 1.) THF/n-hexane, -67 deg C, 30 min, 2.) THF, -67 -63 deg C, then room temperature, 3 h 50 min and 6 h 15 min

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; sodium tetrahydroborate; lithium aluminium tetrahydride; dipyridinium dichromate; n-butyllithium; baker's yeast; phosphate buffer; MS (3 Angstroem); Triton -100; tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; pyridinium chlorochromate; lithium diisopropyl amide; Sucrose; toluene-4-sulfonic acid; In tetrahydrofuran; pyridine; methanol; diethyl ether; ethanol; dichloromethane; water; acetone; acetonitrile; paraffin;

DOI:10.1016/S0040-4020(01)89929-4

Reference yield:

pentane-1,3,5-triol (4328-94-3) → 4-benzyloxy-5-benzyloxymethyl-2-<(3'-tetrahydropyranyloxymethyl)pentylidene>tetrahydropyran (113195-27-0,113299-79-9)

Guidance literature:

Multi-step reaction with 12 steps

1: 98.3 g / p-TsOH*H₂O / acetone

2: 97 percent / pyridinium chlorochromate, MS (3 Angstroem) / CH₂Cl₂

3: 64 percent / p-TsOH*H₂O / CH₂Cl₂ / Heating

4: 72 percent / pyridinium dichromate, MS (3 Angstroem) / CH₂Cl₂

5: 1.) LDA, HMPA, 2.) HMPA / 1.) hexane/THF, -76 -72 deg C, 13 min, then -35 deg C, 2.) -78 deg C, 15 min

6: 11 percent / sucrose, phosphate buffer, baker's yeast, 0.2 percent Triton -100 aq. / 1 h / 30 °C

7: p-TsOH*H₂O / ethanol; H₂O / 168 h / Ambient temperature

8: 4-(N,N-dimethylamino)pyridine / pyridine

9: 97 percent / LAH / diethyl ether

10: 80 percent / NaH (60 percent), n-Bu₄N⁽¹⁺⁾*I^(1-) / paraffin; tetrahydrofuran / 1 h / Heating

11: acetonitrile / 1 h / Heating

12: 1.) HMPA, n-BuLi / 1.) THF/n-hexane, -67 deg C, 30 min, 2.) THF, -67 -63 deg C, then room temperature, 3 h 50 min and 6 h 15 min

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; lithium aluminium tetrahydride; dipyridinium dichromate; n-butyllithium; baker's yeast; phosphate buffer; MS (3 Angstroem); Triton -100; tetra-(n-butyl)ammonium iodide; sodium hydride; pyridinium chlorochromate; lithium diisopropyl amide; Sucrose; toluene-4-sulfonic acid; In tetrahydrofuran; pyridine; diethyl ether; ethanol; dichloromethane; water; acetone; acetonitrile; paraffin;

DOI:10.1016/S0040-4020(01)89929-4

Reference yield:

dimethyl 3-hydroxypentanedioate (7250-55-7) → 4-benzyloxy-5-benzyloxymethyl-2-<(3'-tetrahydropyranyloxymethyl)pentylidene>tetrahydropyran (113195-27-0,113299-79-9)

Guidance literature:

Multi-step reaction with 15 steps

1: p-TsOH*H₂O / diethyl ether

2: LiAlH₄ / diethyl ether

3: p-TsOH*H₂O / methanol

4: 98.3 g / p-TsOH*H₂O / acetone

5: 97 percent / pyridinium chlorochromate, MS (3 Angstroem) / CH₂Cl₂

6: 64 percent / p-TsOH*H₂O / CH₂Cl₂ / Heating

7: 72 percent / pyridinium dichromate, MS (3 Angstroem) / CH₂Cl₂

8: 1.) LDA, HMPA, 2.) HMPA / 1.) hexane/THF, -76 -72 deg C, 13 min, then -35 deg C, 2.) -78 deg C, 15 min

9: 11 percent / sucrose, phosphate buffer, baker's yeast, 0.2 percent Triton -100 aq. / 1 h / 30 °C

10: p-TsOH*H₂O / ethanol; H₂O / 168 h / Ambient temperature

11: 4-(N,N-dimethylamino)pyridine / pyridine

12: 97 percent / LAH / diethyl ether

13: 80 percent / NaH (60 percent), n-Bu₄N⁽¹⁺⁾*I^(1-) / paraffin; tetrahydrofuran / 1 h / Heating

14: acetonitrile / 1 h / Heating

15: 1.) HMPA, n-BuLi / 1.) THF/n-hexane, -67 deg C, 30 min, 2.) THF, -67 -63 deg C, then room temperature, 3 h 50 min and 6 h 15 min

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; lithium aluminium tetrahydride; dipyridinium dichromate; n-butyllithium; baker's yeast; phosphate buffer; MS (3 Angstroem); Triton -100; tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; pyridinium chlorochromate; lithium diisopropyl amide; Sucrose; toluene-4-sulfonic acid; In tetrahydrofuran; pyridine; methanol; diethyl ether; ethanol; dichloromethane; water; acetone; acetonitrile; paraffin;

DOI:10.1016/S0040-4020(01)89929-4

upstream raw materials:

3-oxopentanedioic acid dimethyl ester

pentane-1,3,5-triol

dimethyl 3-hydroxypentanedioate

2-ethoxytetrahydropyran-4-one

Downstream raw materials:

3-benzyloxymethyl-9-ethyl-4-hydroxy-1,7-dioxaspiro<5.5>undecane

4-benzyloxy-3-benzyloxymethyl-9-ethyl-1,7-dioxaspiro<5.5>undecane

C₂₆H₂₆N₄O₁₄

9-ethyl-4-hydroxy-1-hydroxymethyl-1,7-dioxaspiro<5.5>undecane

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 113195-27-0 4-benzyloxy-5-benzyloxymethyl-2-<(3'-tetrahydropyranyloxymethyl)pentylidene>tetrahydropyran

Send

Send

Metric Ton KG G Pound L ML

Send

Send