4'-(Acetylamino)-1,1'-biphenyl-4-sulfonyl chloride

Base Information

• Chemical Name: 4'-(Acetylamino)-1,1'-biphenyl-4-sulfonyl chloride
• CAS No.: 20443-73-6
• Molecular Formula: C₁₄H₁₂ClNO₃S
• Molecular Weight: 309.773
• European Community (EC) Number: 824-617-7
• DSSTox Substance ID: DTXSID50529291
• Wikidata: Q82399636
• Mol file: 20443-73-6.mol

Synonyms:20443-73-6;4'-(acetylamino)-1,1'-biphenyl-4-sulfonyl chloride;4-(4-acetamidophenyl)benzenesulfonyl chloride;4-(4-acetamidophenyl)benzene-1-sulfonyl chloride;4'-Acetamido-[1,1'-biphenyl]-4-sulfonyl chloride;DTXSID50529291;MFCD08271843;EN300-23536;G22877;4'-Acetamido-[1,1'-biphenyl]-4-sulfonylchloride;4'-Acetamido[1,1'-biphenyl]-4-sulfonyl chloride;4'-(acetylamino)-1,1'-biphenyl-4-sulfonyl chloride, AldrichCPR

Chemical Property of 4'-(Acetylamino)-1,1'-biphenyl-4-sulfonyl chloride

Chemical Property:

• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 309.0226421
• Heavy Atom Count: 20
• Complexity: 430

Purity/Quality:

90% ^*data from raw suppliers

4'-Acetamido-[1,1'-biphenyl]-4-sulfonylchloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=CC=C(C=C1)C2=CC=C(C=C2)S(=O)(=O)Cl

Technology Process of 4'-(Acetylamino)-1,1'-biphenyl-4-sulfonyl chloride

There total 2 articles about 4'-(Acetylamino)-1,1'-biphenyl-4-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-phenylacetanilide (4075-79-0) → 4'-acetylamino-biphenyl-4-sulfonyl chloride (20443-73-6)

Guidance literature:

With chlorosulphuric acid;

DOI:10.1021/ja01868a069 DOI:10.1021/ja01847a506

Reference yield:

→ 4'-acetylamino-biphenyl-4-sulfonyl chloride (20443-73-6)

Guidance literature:

4-Acetamidophenylbenzolsulfonsaeure, PCl5;

Reference yield:

4'-acetylamino-biphenyl-4-sulfonyl chloride (20443-73-6) → 4'-(4'-amino-biphenyl-4-sulfonylamino)-biphenyl-4-sulfonic acid amide

Guidance literature:

Multi-step reaction with 2 steps

1: acetone; pyridine

2: aq.-ethanolic hydrochloric acid

With pyridine; hydrogenchloride; acetone;

DOI:10.1021/ja01850a052

upstream raw materials:

4-phenylacetanilide

Downstream raw materials:

4'-amino-biphenyl-4-sulfonic acid

4-sulfamoyl-1,1'-biphenyl-4'-amine

4'-amino-biphenyl-4-sulfonic acid benzylamide