(3aR,4R,5R)-5-(benzoyloxy)-3,3a,4,5,6,7-hexahydro-4-<(2-methoxyethoxy)methoxy>spiro<2,1-benzisoxazole-7,2'-<1,3>dioxolane>

Base Information

• Chemical Name: (3aR,4R,5R)-5-(benzoyloxy)-3,3a,4,5,6,7-hexahydro-4-<(2-methoxyethoxy)methoxy>spiro<2,1-benzisoxazole-7,2'-<1,3>dioxolane>
• CAS No.: 139609-26-0
• Molecular Formula: C₂₀H₂₅NO₈
• Molecular Weight: 407.42
• Mol file: 139609-26-0.mol

Synonyms:

Chemical Property of (3aR,4R,5R)-5-(benzoyloxy)-3,3a,4,5,6,7-hexahydro-4-<(2-methoxyethoxy)methoxy>spiro<2,1-benzisoxazole-7,2'-<1,3>dioxolane>

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3aR,4R,5R)-5-(benzoyloxy)-3,3a,4,5,6,7-hexahydro-4-<(2-methoxyethoxy)methoxy>spiro<2,1-benzisoxazole-7,2'-<1,3>dioxolane>

There total 8 articles about (3aR,4R,5R)-5-(benzoyloxy)-3,3a,4,5,6,7-hexahydro-4-<(2-methoxyethoxy)methoxy>spiro<2,1-benzisoxazole-7,2'-<1,3>dioxolane> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

Benzoic acid (1R,2R)-1-[2-(hydroxyimino-methyl)-[1,3]dioxolan-2-ylmethyl]-2-(2-methoxy-ethoxymethoxy)-but-3-enyl ester (148111-29-9) → (3aS,4R,5R)-5-(benzoyloxy)-3,3a,4,5,6,7-hexahydro-4-<(2-methoxyethoxy)methoxy>spiro<2,1-benzisoxazole-7,2'-<1,3>dioxolane> (139609-26-0,139684-83-6) + (3aR,4R,5R)-5-(benzoyloxy)-3,3a,4,5,6,7-hexahydro-4-<(2-methoxyethoxy)methoxy>spiro<2,1-benzisoxazole-7,2'-<1,3>dioxolane> (139609-26-0,139684-83-6) + (8R,9R)-8-ethenyl-14-hydroxy-11-oxo-2,5,7,12-tetraoxatetradecan-9-yl benzoate

Guidance literature:

With tert-butylhypochlorite; In benzene; at 5 ℃; for 0.5h; Reagent/catalyst; Temperature; Solvent; Inert atmosphere;

DOI:10.1021/jacs.8b06955

Reference yield: 91.0%

Benzoic acid (1R,2R)-1-[2-(hydroxyimino-methyl)-[1,3]dioxolan-2-ylmethyl]-2-(2-methoxy-ethoxymethoxy)-but-3-enyl ester (148111-29-9) → (3aS,4R,5R)-5-(benzoyloxy)-3,3a,4,5,6,7-hexahydro-4-<(2-methoxyethoxy)methoxy>spiro<2,1-benzisoxazole-7,2'-<1,3>dioxolane> (139609-26-0,139684-83-6) + (3aR,4R,5R)-5-(benzoyloxy)-3,3a,4,5,6,7-hexahydro-4-<(2-methoxyethoxy)methoxy>spiro<2,1-benzisoxazole-7,2'-<1,3>dioxolane> (139609-26-0,139684-83-6) + (8R,9R)-8-ethenyl-14-hydroxy-11-oxo-2,5,7,12-tetraoxatetradecan-9-yl benzoate

Guidance literature:

With tert-butylhypochlorite; In benzene; at 5 ℃; for 0.5h; Reagent/catalyst; Temperature; Solvent; Inert atmosphere;

DOI:10.1021/jacs.8b06955

Reference yield: 81.0%

Benzoic acid (1R,2R)-1-[2-(hydroxyimino-methyl)-[1,3]dioxolan-2-ylmethyl]-2-(2-methoxy-ethoxymethoxy)-but-3-enyl ester (148111-29-9) → (3aS,4R,5R)-5-(benzoyloxy)-3,3a,4,5,6,7-hexahydro-4-<(2-methoxyethoxy)methoxy>spiro<2,1-benzisoxazole-7,2'-<1,3>dioxolane> (139609-26-0,139684-83-6)

Guidance literature:

With tert-butylhypochlorite; In benzene; at 25 ℃; for 0.5h;

upstream raw materials:

Benzoic acid (1R,2R)-1-[2-(hydroxyimino-methyl)-[1,3]dioxolan-2-ylmethyl]-2-(2-methoxy-ethoxymethoxy)-but-3-enyl ester

(E)-2-<(2R,3R)-2-(benzoyloxy)-3-<(2-methoxyethoxy)methoxy>pent-4-enyl>-1,3-dioxolane-2-carboxaldehyde oxime

Downstream raw materials:

(2E)-2-{(1R,4Z,8S)-8-hydroxy-10-[(methoxycarbonyl)amino]-1-[(triethylsilyl)oxy]-13H-spiro[bicyclo[7.3.1]trideca-4,9-diene-2,6-diyne-11,2'-[1,3]dioxolan]-13-ylidene}ethyl benzoate

N-{(R)-7-Formyl-9-((Z)-hex-3-ene-1,5-diynyl)-8-[1-methoxycarbonyl-meth-(E)-ylidene]-9-triethylsilanyloxy-1,4-dioxa-spiro[4.5]dec-6-en-6-yl}-phthalamic acid