Technology Process of (2S,5S,10aS,10bS)-2-Benzyloxycarbonylamino-5-benzyl-10b-hydroxy-3,6-dioxo-octahydro-8H-oxazolo(3,2-a)-pyrrolo(2,1-c)-pyrazin
There total 8 articles about (2S,5S,10aS,10bS)-2-Benzyloxycarbonylamino-5-benzyl-10b-hydroxy-3,6-dioxo-octahydro-8H-oxazolo(3,2-a)-pyrrolo(2,1-c)-pyrazin which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium tartrate;
In
acetone;
at 20 ℃;
for 24h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1) HOBt, DCC / 1) ether, CH2Cl2, 0 deg C, 15 min, 2) 0 deg C, 45 min, 20 deg C, 12 h
2: 72.1 percent / CF3COOH / 5 h / 20 °C
3: 41.4 percent / DCC / ethyl acetate / 3 h / 20 °C
4: 42.3 percent / lead tetraacetate / benzene / 0.25 h / Heating
5: 2.5 percent / 10percent potassium tartrate solution / acetone / 24 h / 20 °C
With
lead(IV) acetate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; potassium tartrate;
In
ethyl acetate; acetone; benzene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1) N-methylmorpholine, isobutyl chloroformate, 2) N-methylmorpholine / 1) CHCl3, -20 deg C, 30 min, 2) 2 h, RT
2: 1 N NaOH / dioxane; H2O / 0.75 h / Ambient temperature
3: 41.4 percent / DCC / ethyl acetate / 3 h / 20 °C
4: 42.3 percent / lead tetraacetate / benzene / 0.25 h / Heating
5: 2.5 percent / 10percent potassium tartrate solution / acetone / 24 h / 20 °C
With
4-methyl-morpholine; lead(IV) acetate; sodium hydroxide; dicyclohexyl-carbodiimide; potassium tartrate; isobutyl chloroformate;
In
1,4-dioxane; water; ethyl acetate; acetone; benzene;
