Technology Process of 9E,9Z-9,13-dimethyl-7-(1,5-dimethyl-1-ethoxycarbonyl-4-oxo-5-cyclohexen-6-yl)-7,9,11,13-nonatetraene-15-ol
There total 14 articles about 9E,9Z-9,13-dimethyl-7-(1,5-dimethyl-1-ethoxycarbonyl-4-oxo-5-cyclohexen-6-yl)-7,9,11,13-nonatetraene-15-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium hydroxide;
In
ethanol;
for 0.25h;
Ambient temperature;
in the presence of 4-methyl-2,6-di-tert-butylphenol;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 74.5 percent / C2H5MgBr / tetrahydrofuran; benzene / 7 h / Heating
2: 65 percent / pyridine / CH2Cl2 / 1 h / 0 °C
3: 10.60 g / H2 / Lindlar's catalyst / hexane
4: 65 percent / 18percent aq. HCl / diethyl ether / 0.05 h
5: 2.0 g / NaBH4 / ethanol / 0.67 h / 0 - 5 °C
6: PBr3 / CH2Cl2; dimethylformamide; pyridine / 1.5 h / -15 - -10 °C
7: 2.30 g / CH2Cl2 / 1.5 h / Heating
8: 1) butyllithium / 1) tetrahydrofuran, -30 deg C 2) -30 deg C, 30 min. than raised to room temperature
9: 95 percent / KOH / ethanol / 0.25 h / Ambient temperature; in the presence of 4-methyl-2,6-di-tert-butylphenol
With
pyridine; hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; n-butyllithium; ethylmagnesium bromide; hydrogen; phosphorus tribromide;
Lindlar's catalyst;
In
tetrahydrofuran; pyridine; diethyl ether; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; benzene;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 65 percent / pyridine / CH2Cl2 / 1 h / 0 °C
2: 10.60 g / H2 / Lindlar's catalyst / hexane
3: 65 percent / 18percent aq. HCl / diethyl ether / 0.05 h
4: 2.0 g / NaBH4 / ethanol / 0.67 h / 0 - 5 °C
5: PBr3 / CH2Cl2; dimethylformamide; pyridine / 1.5 h / -15 - -10 °C
6: 2.30 g / CH2Cl2 / 1.5 h / Heating
7: 1) butyllithium / 1) tetrahydrofuran, -30 deg C 2) -30 deg C, 30 min. than raised to room temperature
8: 95 percent / KOH / ethanol / 0.25 h / Ambient temperature; in the presence of 4-methyl-2,6-di-tert-butylphenol
With
pyridine; hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; n-butyllithium; hydrogen; phosphorus tribromide;
Lindlar's catalyst;
In
pyridine; diethyl ether; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;
