trans-1-(4-hydroxyphenyl)-2-isopropylcyclohexane

Base Information

Chemical Name:trans-1-(4-hydroxyphenyl)-2-isopropylcyclohexane
CAS No.:132777-34-5
Molecular Formula:C₁₅H₂₂O
Molecular Weight:218.339
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of trans-1-(4-hydroxyphenyl)-2-isopropylcyclohexane

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Technology Process of trans-1-(4-hydroxyphenyl)-2-isopropylcyclohexane

There total 16 articles about trans-1-(4-hydroxyphenyl)-2-isopropylcyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 132777-22-1
8-(4-hydroxyphenyl)-8-<<(methoxyethoxy)methyl>oxy>-2-methyloct-2-ene

: 132777-34-5,132777-47-0
cis-1-(4-hydroxyphenyl)-2-isopropylcyclohexane

: 132777-34-5,132777-47-0
trans-1-(4-hydroxyphenyl)-2-isopropylcyclohexane

Guidance literature:: With ethylaluminum dichloride; In dichloromethane; at -78 ℃; for 0.166667h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1021/jo00008a049

Reference yield:

: 132777-22-1
8-(4-hydroxyphenyl)-8-<<(methoxyethoxy)methyl>oxy>-2-methyloct-2-ene

: 132777-34-5,132777-47-0
cis-1-(4-hydroxyphenyl)-2-isopropylcyclohexane

: 132777-34-5,132777-47-0
trans-1-(4-hydroxyphenyl)-2-isopropylcyclohexane

Guidance literature:: With ethylaluminum dichloride; In dichloromethane; at -78 ℃; for 0.166667h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1021/jo00008a049

Reference yield:

: 120743-99-9
p-[(tert-butyldimethylsilyl)oxy]benzaldehyde

: 132777-34-5,132777-47-0
cis-1-(4-hydroxyphenyl)-2-isopropylcyclohexane

Guidance literature:: Multi-step reaction with 7 steps

1: 1) n-BuLi / 1) THF, -76 deg C, 10 min, 2) THF, 1 h

2: 90 percent / diisopropylethyl amine / CH₂Cl₂ / 3.5 h / 23 °C

3: 92 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 0 °C

4: 97 percent / pyridine / a) 0 deg C, 15 min, b) 20 min

5: 85 percent / Li₂CuCl₄ / tetrahydrofuran / 6 h / 0 °C

6: 98 percent / (n-Bu)4NF / tetrahydrofuran / 0.33 h / 23 °C

7: EtAlCl₂ / CH₂Cl₂ / 0.17 h / -78 °C

With pyridine; lithium aluminium tetrahydride; n-butyllithium; dilithium tetrachlorocuprate; tetrabutyl ammonium fluoride; ethylaluminum dichloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00008a049