2-[2-(2-{2-[2-(2-{2-[2-(2-Hydroxy-ethoxy)-phenoxy]-ethoxy}-phenoxy)-ethoxy]-phenoxy}-ethoxy)-phenoxymethyl]-benzoic acid methyl ester

Base Information

• Chemical Name: 2-[2-(2-{2-[2-(2-{2-[2-(2-Hydroxy-ethoxy)-phenoxy]-ethoxy}-phenoxy)-ethoxy]-phenoxy}-ethoxy)-phenoxymethyl]-benzoic acid methyl ester
• CAS No.: 101854-02-8
• Molecular Formula: C₄₁H₄₂O₁₁
• Molecular Weight: 710.778
• Mol file: 101854-02-8.mol

Synonyms:

Chemical Property of 2-[2-(2-{2-[2-(2-{2-[2-(2-Hydroxy-ethoxy)-phenoxy]-ethoxy}-phenoxy)-ethoxy]-phenoxy}-ethoxy)-phenoxymethyl]-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-(2-{2-[2-(2-{2-[2-(2-Hydroxy-ethoxy)-phenoxy]-ethoxy}-phenoxy)-ethoxy]-phenoxy}-ethoxy)-phenoxymethyl]-benzoic acid methyl ester

There total 7 articles about 2-[2-(2-{2-[2-(2-{2-[2-(2-Hydroxy-ethoxy)-phenoxy]-ethoxy}-phenoxy)-ethoxy]-phenoxy}-ethoxy)-phenoxymethyl]-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-bromomethylbenzoate (2417-73-4) + 2-<2-<2-<2-<2-<2-<2-(2-hydroxyphenoxy)ethoxy>phenoxy>ethoxy>phenoxy>ethoxy>phenoxy>ethanol (101901-59-1) → 2-[2-(2-{2-[2-(2-{2-[2-(2-Hydroxy-ethoxy)-phenoxy]-ethoxy}-phenoxy)-ethoxy]-phenoxy}-ethoxy)-phenoxymethyl]-benzoic acid methyl ester (101854-02-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 80 ℃;

DOI:10.1039/c39850001468

Reference yield:

2-<2-<2-(2-hydroxyphenoxy)ethoxy>phenoxy>ethanol (65659-47-4) → 2-[2-(2-{2-[2-(2-{2-[2-(2-Hydroxy-ethoxy)-phenoxy]-ethoxy}-phenoxy)-ethoxy]-phenoxy}-ethoxy)-phenoxymethyl]-benzoic acid methyl ester (101854-02-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH, 3.) aq. KOH

2: 1.) NaH / 1.) DMF, 80-90 deg C, 2 h, 2.) DMF, 80-90 deg C, 18 h

With potassium hydroxide; sodium hydride;

DOI:10.1246/bcsj.68.315

Reference yield:

2-(2-hydroxy-phenoxy)-ethanol (4792-78-3) → 2-[2-(2-{2-[2-(2-{2-[2-(2-Hydroxy-ethoxy)-phenoxy]-ethoxy}-phenoxy)-ethoxy]-phenoxy}-ethoxy)-phenoxymethyl]-benzoic acid methyl ester (101854-02-8)

Guidance literature:

Multi-step reaction with 5 steps

1: NaH / dimethylformamide / 80 °C

2: Et₃N

3: NaH / dimethylformamide / 80 °C

4: alkaline hydrolysis and acidification

5: NaH / dimethylformamide / 80 °C

With sodium hydride; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1039/c39850001468

upstream raw materials:

methyl 2-bromomethylbenzoate

2-<2-<2-<2-<2-<2-<2-(2-hydroxyphenoxy)ethoxy>phenoxy>ethoxy>phenoxy>ethoxy>phenoxy>ethanol

2-<2-<2-(2-hydroxyphenoxy)ethoxy>phenoxy>ethanol

2-<2-<2-(3-hydroxyphenoxy)ethoxy>phenoxy>ethanol bis(p-toluenesulfonate)