C₄₃H₄₇N₅O₁₁

Base Information

• Chemical Name: C₄₃H₄₇N₅O₁₁
• CAS No.: 146557-91-7
• Molecular Formula: C₄₃H₄₇N₅O₁₁
• Molecular Weight: 809.873
• Mol file: 146557-91-7.mol

Synonyms:

Chemical Property of C₄₃H₄₇N₅O₁₁

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₃H₄₇N₅O₁₁

There total 7 articles about C₄₃H₄₇N₅O₁₁ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2-deoxy-3-O-tert-butyldiphenylsilyl-β-D-erythro-pentadialdo-1,4-furanosyl)-5-methyluracil (146604-43-5) → C43H47N5O11 (146557-91-7)

Guidance literature:

Multi-step reaction with 6 steps

1: 85 percent / CH₂Cl₂ / 3 h / Ambient temperature

2: H₂ / 10percent Pd/C / methanol / 14 h / 760 Torr / Ambient temperature

3: 2M KOH / H₂O; methanol / 2 h / Ambient temperature

4: 1.) Et₃N, TBTU, N-hydroxybenzotriazole; 2.) Et₃N / 1.) CH₃CN, room temp., 2 h; 2.) room temp., 24 h

5: tetrabutylammonium fluoride / tetrahydrofuran / 12 h / Ambient temperature

6: pyridine / 18 h / Ambient temperature

With pyridine; potassium hydroxide; tetrabutyl ammonium fluoride; hydrogen; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1016/0040-4039(93)85051-W

Reference yield:

(E)-3-[(2R,3S,5R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-acrylic acid methyl ester → C43H47N5O11 (146557-91-7)

Guidance literature:

Multi-step reaction with 5 steps

1: H₂ / 10percent Pd/C / methanol / 14 h / 760 Torr / Ambient temperature

2: 2M KOH / H₂O; methanol / 2 h / Ambient temperature

3: 1.) Et₃N, TBTU, N-hydroxybenzotriazole; 2.) Et₃N / 1.) CH₃CN, room temp., 2 h; 2.) room temp., 24 h

4: tetrabutylammonium fluoride / tetrahydrofuran / 12 h / Ambient temperature

5: pyridine / 18 h / Ambient temperature

With pyridine; potassium hydroxide; tetrabutyl ammonium fluoride; hydrogen; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; water;

DOI:10.1016/0040-4039(93)85051-W

Reference yield:

5'-O-thexyldimethylsilyl-3'-amino-3'-deoxythymidine (123556-91-2) → C43H47N5O11 (146557-91-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) Et₃N, TBTU, N-hydroxybenzotriazole; 2.) Et₃N / 1.) CH₃CN, room temp., 2 h; 2.) room temp., 24 h

2: tetrabutylammonium fluoride / tetrahydrofuran / 12 h / Ambient temperature

3: pyridine / 18 h / Ambient temperature

With pyridine; tetrabutyl ammonium fluoride; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran;

DOI:10.1016/0040-4039(93)85051-W

upstream raw materials:

4,4'-dimethoxytrityl chloride

5'-O-thexyldimethylsilyl-3'-amino-3'-deoxythymidine

1-(2-deoxy-3-O-tert-butyldiphenylsilyl-β-D-erythro-pentadialdo-1,4-furanosyl)-5-methyluracil

3-[(2R,3S,5R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-propionic acid