Acetic acid (3R,4S)-4-(4-methoxy-phenyl)-1-((R)-1-methyl-pyrrolidin-2-ylmethyl)-2-oxo-6-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl ester

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Chemical Name:Acetic acid (3R,4S)-4-(4-methoxy-phenyl)-1-((R)-1-methyl-pyrrolidin-2-ylmethyl)-2-oxo-6-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl ester
CAS No.:128573-84-2
Molecular Formula:C₂₆H₂₉F₃N₂O₄
Molecular Weight:490.522
Hs Code.:

Acetic acid (3R,4S)-4-(4-methoxy-phenyl)-1-((R)-1-methyl-pyrrolidin-2-ylmethyl)-2-oxo-6-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl ester

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Chemical Property of Acetic acid (3R,4S)-4-(4-methoxy-phenyl)-1-((R)-1-methyl-pyrrolidin-2-ylmethyl)-2-oxo-6-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl ester

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Technology Process of Acetic acid (3R,4S)-4-(4-methoxy-phenyl)-1-((R)-1-methyl-pyrrolidin-2-ylmethyl)-2-oxo-6-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl ester

There total 7 articles about Acetic acid (3R,4S)-4-(4-methoxy-phenyl)-1-((R)-1-methyl-pyrrolidin-2-ylmethyl)-2-oxo-6-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 111688-58-5
(3S,4S-trans)-3-carboxy-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one (S)-α-methylbenzylamine salt

: 128573-84-2
Acetic acid (3R,4S)-4-(4-methoxy-phenyl)-1-((R)-1-methyl-pyrrolidin-2-ylmethyl)-2-oxo-6-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / KHCO₃ / dimethylformamide / 5.17 h / 0 - 20 °C

2: 1.) potassium hexamethyldisilazide, 2.) O₂, P(OEt)3 / 1.) THF, -70 deg C, 1 h, 2.) THF, 0 deg C, 2 h

3: 66 percent / LiI, H₂O / pyridine / 2 h / Heating

4: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, from 0 deg C to RT, 3 h

5: (N,N-dimethylamino)pyridine (DMAP) / CH₂Cl₂ / 24 h / Ambient temperature

With dmap; water; oxygen; potassium hexamethylsilazane; sodium hydride; potassium hydrogencarbonate; lithium iodide; triethyl phosphite; In pyridine; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00082a018

Reference yield:

: 3554-65-2,30727-24-3,34381-71-0,99494-01-6
(R)-N-methylpyrrolidine-2-methanol

: 128573-84-2
Acetic acid (3R,4S)-4-(4-methoxy-phenyl)-1-((R)-1-methyl-pyrrolidin-2-ylmethyl)-2-oxo-6-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / CHCl₃ / 2 h / Heating

2: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, from 0 deg C to RT, 3 h

3: (N,N-dimethylamino)pyridine (DMAP) / CH₂Cl₂ / 24 h / Ambient temperature

With dmap; thionyl chloride; sodium hydride; In dichloromethane; chloroform;
DOI:10.1021/jm00082a018

Reference yield:

: 67824-41-3
(R)-2-(chloromethyl)-1-methylpyrrolidine hydrochloride

: 128573-84-2
Acetic acid (3R,4S)-4-(4-methoxy-phenyl)-1-((R)-1-methyl-pyrrolidin-2-ylmethyl)-2-oxo-6-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, from 0 deg C to RT, 3 h

2: (N,N-dimethylamino)pyridine (DMAP) / CH₂Cl₂ / 24 h / Ambient temperature

With dmap; sodium hydride; In dichloromethane;
DOI:10.1021/jm00082a018