[3H]BMS-725519

Base Information

• Chemical Name: [3H]BMS-725519
• CAS No.: 1350454-70-4
• Molecular Formula: C₂₃H₁₄ClF₃N₆O
• Molecular Weight: 486.836
• Mol file: 1350454-70-4.mol

Synonyms:

Chemical Property of [3H]BMS-725519

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [3H]BMS-725519

There total 17 articles about [3H]BMS-725519 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C23H12ClF3I2N6O (1350438-50-4) → [3H]BMS-725519 (1350454-70-4)

Guidance literature:

With tritium; palladium 10% on activated carbon; triethylamine; In ethanol; at 20 ℃; for 3h;

DOI:10.1016/j.bmcl.2011.09.016

Reference yield:

2-chloro-3-(chloromethyl)-6-(trifluoromethyl)pyridine (917969-77-8) → [3H]BMS-725519 (1350454-70-4)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 80 °C

2: chloro-trimethyl-silane; sodium iodide / acetonitrile / 180 °C / Microwave irradiation

3: palladium 10% on activated carbon; tritium; triethylamine / ethanol / 3 h / 20 °C

With chloro-trimethyl-silane; tritium; palladium 10% on activated carbon; potassium carbonate; triethylamine; sodium iodide; In ethanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.bmcl.2011.09.016

Reference yield:

C23H12Cl2F3IN6O (1350438-49-1) → [3H]BMS-725519 (1350454-70-4)

Guidance literature:

Multi-step reaction with 2 steps

1: chloro-trimethyl-silane; sodium iodide / acetonitrile / 180 °C / Microwave irradiation

2: palladium 10% on activated carbon; tritium; triethylamine / ethanol / 3 h / 20 °C

With chloro-trimethyl-silane; tritium; palladium 10% on activated carbon; triethylamine; sodium iodide; In ethanol; acetonitrile;

DOI:10.1016/j.bmcl.2011.09.016

upstream raw materials:

C₁₅H₈Cl₂IN₃

C₁₆H₉ClIN₅O

2-chloro-3-(chloromethyl)-6-(trifluoromethyl)pyridine

C₂₃H₁₂Cl₂F₃IN₆O