(S)-Pyrrolidine-1,2-dicarboxylic acid 2-[(2S,6R)-6-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-trityl-morpholin-2-ylmethyl] ester 1-(9H-fluoren-9-ylmethyl) ester

Base Information

Chemical Name:(S)-Pyrrolidine-1,2-dicarboxylic acid 2-[(2S,6R)-6-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-trityl-morpholin-2-ylmethyl] ester 1-(9H-fluoren-9-ylmethyl) ester
CAS No.:139578-71-5
Molecular Formula:C₅₅H₄₉N₅O₇
Molecular Weight:892.023
Hs Code.:

(S)-Pyrrolidine-1,2-dicarboxylic acid 2-[(2S,6R)-6-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-trityl-morpholin-2-ylmethyl] ester 1-(9H-fluoren-9-ylmethyl) ester

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Chemical Property of (S)-Pyrrolidine-1,2-dicarboxylic acid 2-[(2S,6R)-6-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-trityl-morpholin-2-ylmethyl] ester 1-(9H-fluoren-9-ylmethyl) ester

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Technology Process of (S)-Pyrrolidine-1,2-dicarboxylic acid 2-[(2S,6R)-6-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-trityl-morpholin-2-ylmethyl] ester 1-(9H-fluoren-9-ylmethyl) ester

There total 1 articles about (S)-Pyrrolidine-1,2-dicarboxylic acid 2-[(2S,6R)-6-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-trityl-morpholin-2-ylmethyl] ester 1-(9H-fluoren-9-ylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 71989-31-6
Fmoc-Pro-OH

: 125515-31-3
N-{1-[(2R,6)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl}benzamide

: 139578-71-5
(S)-Pyrrolidine-1,2-dicarboxylic acid 2-[(2S,6R)-6-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-trityl-morpholin-2-ylmethyl] ester 1-(9H-fluoren-9-ylmethyl) ester

Guidance literature:: With pyridine; diimide;
DOI:10.1016/0040-4039(91)80113-K

Reference yield:

: 139578-71-5
(S)-Pyrrolidine-1,2-dicarboxylic acid 2-[(2S,6R)-6-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-trityl-morpholin-2-ylmethyl] ester 1-(9H-fluoren-9-ylmethyl) ester

: (S)-Pyrrolidine-2-carboxylic acid (2S,6R)-6-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-trityl-morpholin-2-ylmethyl ester

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 50 ℃;
DOI:10.1016/0040-4039(91)80113-K

Reference yield:

: 139578-71-5
(S)-Pyrrolidine-1,2-dicarboxylic acid 2-[(2S,6R)-6-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-trityl-morpholin-2-ylmethyl] ester 1-(9H-fluoren-9-ylmethyl) ester

: 139578-73-7
(2S,4R)-2-{(S)-2-[(2S,6R)-6-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-trityl-morpholin-2-ylmethoxycarbonyl]-pyrrolidine-1-carbonyl}-4-hydroxy-pyrrolidine-1-carboxylic acid 2-benzenesulfonyl-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / dimethylformamide / 50 °C

With triethylamine; In N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(91)80113-K