Technology Process of (2R*S*,3R*,4R*)-6-<(benzylthio)methylene>-2,3-dimethyl-4-(tetrahydropyran-2-yloxy)cyclohexanone
There total 13 articles about (2R*S*,3R*,4R*)-6-<(benzylthio)methylene>-2,3-dimethyl-4-(tetrahydropyran-2-yloxy)cyclohexanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 99 percent / H2 / Raney nickel (W-7) / methanol / 4 h / 130 °C / 95616.1 Torr
2: 8N Jones chromic acid reagent / acetone / 1 h / Ambient temperature
3: p-toluenesulfonic acid monohydrate / benzene / 20 h / Heating; azeotropic removal of water
4: p-toluenesulfonic acid monohydrate, H2O / acetone / 2 h / Heating
5: 86 percent / Na, isopropyl alcohol / toluene / 1 h / Heating
6: 85 percent / 0.5N HCl / tetrahydrofuran / 1 h / Heating
7: 97 percent / pyridinium p-toluenesulfonate / CH2Cl2 / 20 h / Ambient temperature
8: 60 percent NaH (mineraloil) / benzene / 20 h / Ambient temperature
9: 1.)p-toluenesulfonyl chloride, pyridine / 1.) 0 deg C, 3 h, 2.) 0 deg C, 20 h
With
pyridine; hydrogenchloride; water; hydrogen; sodium; pyridinium p-toluenesulfonate; chromic acid; sodium hydride; toluene-4-sulfonic acid; p-toluenesulfonyl chloride; isopropyl alcohol;
Raney nickel (W-7);
In
tetrahydrofuran; methanol; dichloromethane; acetone; toluene; benzene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 97 percent / pyridinium p-toluenesulfonate / CH2Cl2 / 20 h / Ambient temperature
2: 60 percent NaH (mineraloil) / benzene / 20 h / Ambient temperature
3: 1.)p-toluenesulfonyl chloride, pyridine / 1.) 0 deg C, 3 h, 2.) 0 deg C, 20 h
With
pyridine; pyridinium p-toluenesulfonate; sodium hydride; p-toluenesulfonyl chloride;
In
dichloromethane; benzene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 68 percent / TosOH
2: 68 percent
4: 85 percent / 0.5N HCl / tetrahydrofuran / 1 h / Heating
5: 97 percent / pyridinium p-toluenesulfonate / CH2Cl2 / 20 h / Ambient temperature
6: 60 percent NaH (mineraloil) / benzene / 20 h / Ambient temperature
7: 1.)p-toluenesulfonyl chloride, pyridine / 1.) 0 deg C, 3 h, 2.) 0 deg C, 20 h
With
pyridine; hydrogenchloride; pyridinium p-toluenesulfonate; sodium hydride; toluene-4-sulfonic acid; p-toluenesulfonyl chloride;
In
tetrahydrofuran; dichloromethane; benzene;
