Technology Process of 1,2-O-isopropylidene-5,6,7,8,9-penta-deoxy-5,9-(N-benzoxycarbonyl-imino)-β-L-ido-nona-1,4-furanose
There total 9 articles about 1,2-O-isopropylidene-5,6,7,8,9-penta-deoxy-5,9-(N-benzoxycarbonyl-imino)-β-L-ido-nona-1,4-furanose which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 13 percent / TMSOTf / tetrahydrofuran / 2 h / -78 °C
2: 80 percent / Zn; Cu(OAc)2 / acetic acid / 1 h / 70 °C
3: 71 percent / K2CO3 / dimethylformamide / 18 h / 25 °C
4: 78 percent / benzylidene-bis-tricyclohexylphosphine-dichlororuthenium / benzene / 18 h / Heating
5: H2 / Pd/C / methanol / 12 h / 25 °C
6: NaHCO3 / aq. ethanol / 2 h / 0 - 20 °C
With
copper diacetate; trimethylsilyl trifluoromethanesulfonate; hydrogen; sodium hydrogencarbonate; potassium carbonate; zinc;
palladium on activated charcoal; Grubbs catalyst first generation;
In
tetrahydrofuran; methanol; ethanol; acetic acid; N,N-dimethyl-formamide; benzene;
DOI:10.1055/s-2004-829538
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 71 percent / K2CO3 / dimethylformamide / 18 h / 25 °C
2: 78 percent / benzylidene-bis-tricyclohexylphosphine-dichlororuthenium / benzene / 18 h / Heating
3: H2 / Pd/C / methanol / 12 h / 25 °C
4: NaHCO3 / aq. ethanol / 2 h / 0 - 20 °C
With
hydrogen; sodium hydrogencarbonate; potassium carbonate;
palladium on activated charcoal; Grubbs catalyst first generation;
In
methanol; ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1055/s-2004-829538
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 80 percent / Zn; Cu(OAc)2 / acetic acid / 1 h / 70 °C
2: 71 percent / K2CO3 / dimethylformamide / 18 h / 25 °C
3: 78 percent / benzylidene-bis-tricyclohexylphosphine-dichlororuthenium / benzene / 18 h / Heating
4: H2 / Pd/C / methanol / 12 h / 25 °C
5: NaHCO3 / aq. ethanol / 2 h / 0 - 20 °C
With
copper diacetate; hydrogen; sodium hydrogencarbonate; potassium carbonate; zinc;
palladium on activated charcoal; Grubbs catalyst first generation;
In
methanol; ethanol; acetic acid; N,N-dimethyl-formamide; benzene;
DOI:10.1055/s-2004-829538
