Technology Process of 1β-tert-butoxy-2,3,3aα,4,5,7,8,8a-octahydro-4α,8aβ-dimethyl-7α-phenylseleno-6(1H)-azulenone
There total 9 articles about 1β-tert-butoxy-2,3,3aα,4,5,7,8,8a-octahydro-4α,8aβ-dimethyl-7α-phenylseleno-6(1H)-azulenone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: hydrogen / PtO2 / methanol / 2 h / Ambient temperature
3: 1.) LDA / 1.) hexane, THF, -78 degC, 30 min; -50 degC, 5 min; 2.) THF, 1 h, -78 degC
With
hydrogen; lithium diisopropyl amide;
platinum(IV) oxide;
In
methanol;
DOI:10.1248/cpb.31.114
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) hydrogen / 1.) PtO2 / 1.) ethyl acetate, methanol, 2 h, r.t; 2.) DMSO, formalin, piperidine, 0 degC, 30 min; 1 h, r.t.
2: hydrogen / PtO2 / methanol / 2 h / Ambient temperature
4: 1.) LDA / 1.) hexane, THF, -78 degC, 30 min; -50 degC, 5 min; 2.) THF, 1 h, -78 degC
With
hydrogen; lithium diisopropyl amide;
platinum(IV) oxide;
In
methanol;
DOI:10.1248/cpb.31.114
- Guidance literature:
-
Multi-step reaction with 4 steps
1: H2 / PtO2 / methanol / 2280 Torr
2: MeONa / methanol
3: 1.) lithium diisopropylamide, 2. butyllithium / 1.) THF, -78 deg C
4: lithium diisopropylamide / tetrahydrofuran
With
n-butyllithium; hydrogen; sodium methylate; lithium diisopropyl amide;
platinum(IV) oxide;
In
tetrahydrofuran; methanol;
DOI:10.1248/cpb.29.2733
