3α-(6-carboxy-hex-2Z-enyl)-2β-(4-p-fluorophenoxybut-1E-en-3-onyl)-7α-oxabicyclo<2.2.1>heptane

Base Information

Chemical Name:3α-(6-carboxy-hex-2Z-enyl)-2β-(4-p-fluorophenoxybut-1E-en-3-onyl)-7α-oxabicyclo<2.2.1>heptane
CAS No.:119119-40-3
Molecular Formula:C₂₃H₂₇FO₅
Molecular Weight:402.463
Hs Code.:

Synonyms:

Suppliers and Price of 3α-(6-carboxy-hex-2Z-enyl)-2β-(4-p-fluorophenoxybut-1E-en-3-onyl)-7α-oxabicyclo<2.2.1>heptane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3α-(6-carboxy-hex-2Z-enyl)-2β-(4-p-fluorophenoxybut-1E-en-3-onyl)-7α-oxabicyclo<2.2.1>heptane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3α-(6-carboxy-hex-2Z-enyl)-2β-(4-p-fluorophenoxybut-1E-en-3-onyl)-7α-oxabicyclo<2.2.1>heptane

There total 16 articles about 3α-(6-carboxy-hex-2Z-enyl)-2β-(4-p-fluorophenoxybut-1E-en-3-onyl)-7α-oxabicyclo<2.2.1>heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 119119-31-2,141900-13-2
2α-hydroxymethyl-3α-vinyl-7α-oxabicyclo<2.2.1>heptane

: 119119-40-3,119238-76-5
3α-(6-carboxyhex-2Z-enyl)-2α-(4-p-fluorophenoxybut-1E-en-3-onyl)-7α-oxabicyclo<2.2.1>heptane

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) DCC, DMSO 2.) pyridinium trifluoroacetate / 1.) benzene, room t., 2.) benzene, 70 deg C, 20 min

2: DBU / CHCl₃ / 1 h / Ambient temperature

3: CH(OMe)3 / p-Tos-OH / 48 h / Ambient temperature

4: 1.) 0.5 M 9-BBN(THF) 2.) 3 M aq. NaOH, 30percent H₂O₂ / 1.) THF, 0 deg C to room t., 90 min, 2.) THF, 0 deg C, 15 min

5: 76 percent / PCC, NaOAc / CH₂Cl₂ / 2 h / 23 °C

6: 1.) BuLi(hexane) / 1.) DMSO, with cooling, then 10 min, 23 deg C, 2.) DMSO, 23 deg C

7: 50percent aq. HCl / CHCl₃; propan-2-ol / 0.5 h

8: 1.) NaH / 1.) THF, 23 deg C, 1 h 2.) THF, 0 deg C, then 45 deg C, 3 h

With hydrogenchloride; sodium hydroxide; n-butyllithium; 9-BBN-THF; dihydrogen peroxide; sodium acetate; pyridinium trifluroacetate; sodium hydride; dimethyl sulfoxide; dicyclohexyl-carbodiimide; pyridinium chlorochromate; trimethyl orthoformate; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; chloroform; isopropyl alcohol;
DOI:10.1016/0223-5234(88)90209-7

Reference yield:

: 119119-31-2,141900-13-2
2α-hydroxymethyl-3α-vinyl-7α-oxabicyclo<2.2.1>heptane

: 119119-40-3,119238-76-5
3α-(6-carboxy-hex-2Z-enyl)-2β-(4-p-fluorophenoxybut-1E-en-3-onyl)-7α-oxabicyclo<2.2.1>heptane

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) DCC, DMSO 2.) pyridinium trifluoroacetate / 1.) benzene, room t., 2.) benzene, 70 deg C, 20 min

2: DBU / CHCl₃ / 1 h / Ambient temperature

3: CH(OMe)3 / p-Tos-OH / 48 h / Ambient temperature

4: 1.) 0.5 M 9-BBN(THF) 2.) 3 M aq. NaOH, 30percent H₂O₂ / 1.) THF, 0 deg C to room t., 90 min, 2.) THF, 0 deg C, 15 min

5: 76 percent / PCC, NaOAc / CH₂Cl₂ / 2 h / 23 °C

6: 1.) BuLi(hexane) / 1.) DMSO, with cooling, then 10 min, 23 deg C, 2.) DMSO, 23 deg C

7: 50percent aq. HCl / CHCl₃; propan-2-ol / 0.5 h

8: 1.) NaH / 1.) THF, 23 deg C, 1 h 2.) THF, 0 deg C, then 45 deg C, 3 h

With hydrogenchloride; sodium hydroxide; n-butyllithium; 9-BBN-THF; dihydrogen peroxide; sodium acetate; pyridinium trifluroacetate; sodium hydride; dimethyl sulfoxide; dicyclohexyl-carbodiimide; pyridinium chlorochromate; trimethyl orthoformate; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; chloroform; isopropyl alcohol;
DOI:10.1016/0223-5234(88)90209-7

Reference yield:

: 119119-32-3,119238-72-1
(1S,3S,4R)-3-Vinyl-7-oxa-bicyclo[2.2.1]heptane-2-carbaldehyde

: 119119-40-3,119238-76-5
3α-(6-carboxyhex-2Z-enyl)-2α-(4-p-fluorophenoxybut-1E-en-3-onyl)-7α-oxabicyclo<2.2.1>heptane

Guidance literature:: Multi-step reaction with 6 steps

1: CH(OMe)3 / p-Tos-OH / 48 h / Ambient temperature

2: 1.) 0.5 M 9-BBN(THF) 2.) 3 M aq. NaOH, 30percent H₂O₂ / 1.) THF, 0 deg C to room t., 90 min, 2.) THF, 0 deg C, 15 min

3: 76 percent / PCC, NaOAc / CH₂Cl₂ / 2 h / 23 °C

4: 1.) BuLi(hexane) / 1.) DMSO, with cooling, then 10 min, 23 deg C, 2.) DMSO, 23 deg C

5: 50percent aq. HCl / CHCl₃; propan-2-ol / 0.5 h

6: 1.) NaH / 1.) THF, 23 deg C, 1 h 2.) THF, 0 deg C, then 45 deg C, 3 h

With hydrogenchloride; sodium hydroxide; n-butyllithium; 9-BBN-THF; dihydrogen peroxide; sodium acetate; sodium hydride; pyridinium chlorochromate; trimethyl orthoformate; toluene-4-sulfonic acid; In dichloromethane; chloroform; isopropyl alcohol;
DOI:10.1016/0223-5234(88)90209-7