(R)-2-[(1S,2S,4S,6S)-2-(tert-Butyl-dimethyl-silanyloxy)-4-methyl-6-(2-trimethylsilanyl-ethoxymethoxy)-cyclohexyl]-6-methyl-hept-5-en-3-yn-2-ol

Base Information

Chemical Name:(R)-2-[(1S,2S,4S,6S)-2-(tert-Butyl-dimethyl-silanyloxy)-4-methyl-6-(2-trimethylsilanyl-ethoxymethoxy)-cyclohexyl]-6-methyl-hept-5-en-3-yn-2-ol
CAS No.:110211-68-2
Molecular Formula:C₂₇H₅₂O₄Si₂
Molecular Weight:496.878
Hs Code.:

(R)-2-[(1S,2S,4S,6S)-2-(tert-Butyl-dimethyl-silanyloxy)-4-methyl-6-(2-trimethylsilanyl-ethoxymethoxy)-cyclohexyl]-6-methyl-hept-5-en-3-yn-2-ol

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Chemical Property of (R)-2-[(1S,2S,4S,6S)-2-(tert-Butyl-dimethyl-silanyloxy)-4-methyl-6-(2-trimethylsilanyl-ethoxymethoxy)-cyclohexyl]-6-methyl-hept-5-en-3-yn-2-ol

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Technology Process of (R)-2-[(1S,2S,4S,6S)-2-(tert-Butyl-dimethyl-silanyloxy)-4-methyl-6-(2-trimethylsilanyl-ethoxymethoxy)-cyclohexyl]-6-methyl-hept-5-en-3-yn-2-ol

There total 8 articles about (R)-2-[(1S,2S,4S,6S)-2-(tert-Butyl-dimethyl-silanyloxy)-4-methyl-6-(2-trimethylsilanyl-ethoxymethoxy)-cyclohexyl]-6-methyl-hept-5-en-3-yn-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110211-67-1
Acetic acid (R)-1-[(1S,2S,4S,6S)-2-(tert-butyl-dimethyl-silanyloxy)-4-methyl-6-(2-trimethylsilanyl-ethoxymethoxy)-cyclohexyl]-1,5-dimethyl-hex-4-en-2-ynyl ester

: 110211-68-2
(R)-2-[(1S,2S,4S,6S)-2-(tert-Butyl-dimethyl-silanyloxy)-4-methyl-6-(2-trimethylsilanyl-ethoxymethoxy)-cyclohexyl]-6-methyl-hept-5-en-3-yn-2-ol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; Yield given;
DOI:10.1016/S0040-4039(00)85112-6

Reference yield:

: 7214-50-8
5-methylcyclohex-2-en-1-one

: 110211-68-2
(R)-2-[(1S,2S,4S,6S)-2-(tert-Butyl-dimethyl-silanyloxy)-4-methyl-6-(2-trimethylsilanyl-ethoxymethoxy)-cyclohexyl]-6-methyl-hept-5-en-3-yn-2-ol

Guidance literature:: Multi-step reaction with 8 steps

1: 61 percent / Et₃N / diethyl ether

2: NaBH₄ / methanol

3: 100 percent / Raney Ni, conc. HCl / H₂O / 4 h / 0 °C

4: imidazole / dimethylformamide

5: 98 percent / n-butyllithium / hexane; tetrahydrofuran / 13 h / -78 - -20 °C

6: 94 percent / pyridine

7: 96 percent / various solvent(s)

8: LiAlH₄ / diethyl ether / 0 °C

With 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; nickel; triethylamine; In tetrahydrofuran; pyridine; methanol; diethyl ether; hexane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)85112-6

Reference yield:

: 110211-61-5
dimethyl-4,9 oxa-7 aza-8 bicyclo-<4,3,0> nonene-8 one-2

: 110211-68-2
(R)-2-[(1S,2S,4S,6S)-2-(tert-Butyl-dimethyl-silanyloxy)-4-methyl-6-(2-trimethylsilanyl-ethoxymethoxy)-cyclohexyl]-6-methyl-hept-5-en-3-yn-2-ol

Guidance literature:: Multi-step reaction with 7 steps

1: NaBH₄ / methanol

2: 100 percent / Raney Ni, conc. HCl / H₂O / 4 h / 0 °C

3: imidazole / dimethylformamide

4: 98 percent / n-butyllithium / hexane; tetrahydrofuran / 13 h / -78 - -20 °C

5: 94 percent / pyridine

6: 96 percent / various solvent(s)

7: LiAlH₄ / diethyl ether / 0 °C

With 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; nickel; In tetrahydrofuran; pyridine; methanol; diethyl ether; hexane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)85112-6