N-(6-(2-hydroxyethoxy)-2-(2-methoxyethoxy)-5-(2-methoxyphenoxy)pyrimidin-4-yl)-N'-benzylsulfamide

Base Information

Chemical Name:N-(6-(2-hydroxyethoxy)-2-(2-methoxyethoxy)-5-(2-methoxyphenoxy)pyrimidin-4-yl)-N'-benzylsulfamide
CAS No.:1393813-68-7
Molecular Formula:C₂₃H₂₈N₄O₈S
Molecular Weight:520.563
Hs Code.:

Synonyms:

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Chemical Property of N-(6-(2-hydroxyethoxy)-2-(2-methoxyethoxy)-5-(2-methoxyphenoxy)pyrimidin-4-yl)-N'-benzylsulfamide

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Technology Process of N-(6-(2-hydroxyethoxy)-2-(2-methoxyethoxy)-5-(2-methoxyphenoxy)pyrimidin-4-yl)-N'-benzylsulfamide

There total 9 articles about N-(6-(2-hydroxyethoxy)-2-(2-methoxyethoxy)-5-(2-methoxyphenoxy)pyrimidin-4-yl)-N'-benzylsulfamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 109-86-4,95507-80-5
2-methoxy-ethanol

: 441797-10-0
N-(6-(2-hydroxyethoxy)-2-methylsulfonyl-5-(2-methoxyphenoxy)pyrimidin-4-yl)-N'-benzylsulfamide

: 1393813-68-7
N-(6-(2-hydroxyethoxy)-2-(2-methoxyethoxy)-5-(2-methoxyphenoxy)pyrimidin-4-yl)-N'-benzylsulfamide

Guidance literature:: With potassium tert-butylate; at 70 ℃; for 20h;
DOI:10.1021/jm3009103

Reference yield:

: 38768-62-6
methyl (2-methoxyphenoxy) ethanoate

: 1393813-68-7
N-(6-(2-hydroxyethoxy)-2-(2-methoxyethoxy)-5-(2-methoxyphenoxy)pyrimidin-4-yl)-N'-benzylsulfamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 5 h / 40 - 45 °C

1.2: 24 h / 20 - 32 °C

2.1: sodium methylate / methanol / 0.5 h

2.2: 24 h / 10 °C

3.1: potassium carbonate / dimethyl sulfoxide / 0.5 h

3.2: 4.17 h

4.1: trichlorophosphate / N,N-dimethyl-aniline / 3.5 h / Reflux

5.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 16 h / 20 °C

6.1: potassium tert-butylate / 149 h / 60 °C

7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3.5 h / 0 - 20 °C

8.1: potassium tert-butylate / 20 h / 70 °C

With potassium tert-butylate; sodium methylate; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-aniline; mineral oil;
DOI:10.1021/jm3009103

Reference yield:

: 329924-14-3
5-(o-methoxyphenoxy)-2-thioxo-dihydro-pyrimidine-4,6-dione

: 1393813-68-7
N-(6-(2-hydroxyethoxy)-2-(2-methoxyethoxy)-5-(2-methoxyphenoxy)pyrimidin-4-yl)-N'-benzylsulfamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / dimethyl sulfoxide / 0.5 h

1.2: 4.17 h

2.1: trichlorophosphate / N,N-dimethyl-aniline / 3.5 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 16 h / 20 °C

4.1: potassium tert-butylate / 149 h / 60 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3.5 h / 0 - 20 °C

6.1: potassium tert-butylate / 20 h / 70 °C

With potassium tert-butylate; potassium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-aniline;
DOI:10.1021/jm3009103