Z(OMe)-Arg(Mts)-Asn-NH₂

Base Information

• Chemical Name: Z(OMe)-Arg(Mts)-Asn-NH₂
• CAS No.: 112674-43-8
• Molecular Formula: C₂₈H₃₉N₇O₈S
• Molecular Weight: 633.726
• Mol file: 112674-43-8.mol

Synonyms:

Chemical Property of Z(OMe)-Arg(Mts)-Asn-NH₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Z(OMe)-Arg(Mts)-Asn-NH₂

There total 1 articles about Z(OMe)-Arg(Mts)-Asn-NH₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-asparagine (70-47-3,28088-48-4,7006-34-0) + Z(OMe)-Arg(Mts)-OH (68262-73-7) → Z(OMe)-Arg(Mts)-Asn-NH2 (112674-43-8)

Guidance literature:

With isobutyl chloroformate; Yield given. Multistep reaction;

DOI:10.1248/cpb.35.1076

Reference yield:

Z(OMe)-Arg(Mts)-Asn-NH2 (112674-43-8) → Z(OMe)-Phe-Arg(Mts)-Pro-Arg(Mts)-Asn-NH2 (112674-46-1)

Guidance literature:

Multi-step reaction with 4 steps

1: trifluoroacetic acid, anisole

2: 1.) N-hydroxysuccinimid, dicyclohexylcarbodiimide; 2.) Et₃N / 1.) THF, 5 h, r.t.; 2.) THF, DMF, r.t.

3: trifluoroacetic acid, anosole

4: 78 percent / Et₃N / dimethylformamide / Ambient temperature

With 1-hydroxy-pyrrolidine-2,5-dione; methoxybenzene; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.35.1076

Reference yield:

Z(OMe)-Arg(Mts)-Asn-NH2 (112674-43-8) → H-Phe-Arg(Mts)-Pro-Arg(Mts)-Asn-NH2

Guidance literature:

Multi-step reaction with 5 steps

1: trifluoroacetic acid, anisole

2: 1.) N-hydroxysuccinimid, dicyclohexylcarbodiimide; 2.) Et₃N / 1.) THF, 5 h, r.t.; 2.) THF, DMF, r.t.

3: trifluoroacetic acid, anosole

4: 78 percent / Et₃N / dimethylformamide / Ambient temperature

5: trifluoroacetic acid, anisole

With 1-hydroxy-pyrrolidine-2,5-dione; methoxybenzene; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.35.1076

upstream raw materials:

L-asparagine

Z(OMe)-Arg(Mts)-OH

Downstream raw materials:

Z(OMe)-Phe-Arg(Mts)-Pro-Arg(Mts)-Asn-NH₂

Z(OMe)-Arg(Mts)-Pro-Arg(Mts)-Asn-NH₂