(S)-2-{4-[(2-Amino-5-chloro-4-hydroxy-quinazolin-6-ylamino)-methyl]-benzoylamino}-pentanedioic acid; compound with trifluoro-acetic acid

Base Information

Chemical Name:(S)-2-{4-[(2-Amino-5-chloro-4-hydroxy-quinazolin-6-ylamino)-methyl]-benzoylamino}-pentanedioic acid; compound with trifluoro-acetic acid
CAS No.:108947-92-8
Molecular Formula:3C₂HF₃O₂*2C₂₁H₂₀ClN₅O₆
Molecular Weight:1289.82
Hs Code.:

(S)-2-{4-[(2-Amino-5-chloro-4-hydroxy-quinazolin-6-ylamino)-methyl]-benzoylamino}-pentanedioic acid; compound with trifluoro-acetic acid

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Chemical Property of (S)-2-{4-[(2-Amino-5-chloro-4-hydroxy-quinazolin-6-ylamino)-methyl]-benzoylamino}-pentanedioic acid; compound with trifluoro-acetic acid

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Technology Process of (S)-2-{4-[(2-Amino-5-chloro-4-hydroxy-quinazolin-6-ylamino)-methyl]-benzoylamino}-pentanedioic acid; compound with trifluoro-acetic acid

There total 8 articles about (S)-2-{4-[(2-Amino-5-chloro-4-hydroxy-quinazolin-6-ylamino)-methyl]-benzoylamino}-pentanedioic acid; compound with trifluoro-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 108947-97-3
di-tert-butyl 5-chloro-5,8-dideazaisofolate

: 76-05-1
trifluoroacetic acid

: 108947-92-8
(S)-2-{4-[(2-Amino-5-chloro-4-hydroxy-quinazolin-6-ylamino)-methyl]-benzoylamino}-pentanedioic acid; compound with trifluoro-acetic acid

Guidance literature:: for 1h; Ambient temperature;
DOI:10.1021/jm00391a042

Reference yield:

: 6287-86-1
p-ethoxycarbonylbenzaldehyde

: 108947-92-8
(S)-2-{4-[(2-Amino-5-chloro-4-hydroxy-quinazolin-6-ylamino)-methyl]-benzoylamino}-pentanedioic acid; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 66 percent / ethanol / 35 h / Heating

2: 78 percent / (CH₃)2NH*BH₃ / acetic acid / 5 h / Ambient temperature

3: 0.2 N aq. NaOH / acetone / 18 h / Ambient temperature

4: 1 N aq. NaOH / dimethylformamide / 1.5 h / Heating

5: 1.) Et₃N, diethyl phosphorocyanidate, 2.) Et₃N / 1.) DMF, 60-65 deg C, 0.25 h, 2.) DMF, 60-65 deg C, 18 h

6: 57 percent / 1 h / Ambient temperature

With sodium hydroxide; diethyl cyanophosphonate; dimethylamine borane; triethylamine; In ethanol; acetic acid; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00391a042

Reference yield:

: 108947-94-0,108948-01-2
6-<(p-carbethoxybenzylidene)amino>-5-chloro-2,4-diaminoquinazoline

: 108947-92-8
(S)-2-{4-[(2-Amino-5-chloro-4-hydroxy-quinazolin-6-ylamino)-methyl]-benzoylamino}-pentanedioic acid; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / (CH₃)2NH*BH₃ / acetic acid / 5 h / Ambient temperature

2: 0.2 N aq. NaOH / acetone / 18 h / Ambient temperature

3: 1 N aq. NaOH / dimethylformamide / 1.5 h / Heating

4: 1.) Et₃N, diethyl phosphorocyanidate, 2.) Et₃N / 1.) DMF, 60-65 deg C, 0.25 h, 2.) DMF, 60-65 deg C, 18 h

5: 57 percent / 1 h / Ambient temperature

With sodium hydroxide; diethyl cyanophosphonate; dimethylamine borane; triethylamine; In acetic acid; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00391a042