4t-furan-3-yl-1c,7t-dimethyl-(9ar)-octahydro-quinolizin-2-one; picrate

Base Information

• Chemical Name: 4t-furan-3-yl-1c,7t-dimethyl-(9ar)-octahydro-quinolizin-2-one; picrate
• CAS No.: 62724-11-2
• Molecular Formula: C₆H₃N₃O₇*C₁₅H₂₁NO₂
• Molecular Weight: 476.443
• Mol file: 62724-11-2.mol

Synonyms:

Chemical Property of 4t-furan-3-yl-1c,7t-dimethyl-(9ar)-octahydro-quinolizin-2-one; picrate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4t-furan-3-yl-1c,7t-dimethyl-(9ar)-octahydro-quinolizin-2-one; picrate

There total 5 articles about 4t-furan-3-yl-1c,7t-dimethyl-(9ar)-octahydro-quinolizin-2-one; picrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

furan-3-carboxaldehyde (498-60-2) + 3-(5-methyl-2-piperidyl)butan-2-one (62740-48-1) → 4t-furan-3-yl-1c,7t-dimethyl-(9ar)-octahydro-quinolizin-2-one; picrate (62724-11-2,62724-13-4,62724-15-6) + 1,7-dimethyl-4-(3-furyl)quinolizidin-2-one (62724-10-1,62724-12-3,62724-14-5,62751-65-9) + 1,7-dimethyl-4-(3-furyl)quinolizidin-2-one (62724-10-1,62724-12-3,62724-14-5,62751-65-9) + 1,7-dimethyl-4-(3-furyl)quinolizidin-2-one (62724-10-1,62724-12-3,62724-14-5,62751-65-9)

Guidance literature:

With sodium hydroxide; In methanol; 1.) r.t., 10 h, 2.) 80 deg C, 5 h;

DOI:10.1248/cpb.28.831

Reference yield:

2-ethyl-5-methylpyridine (18113-81-0) → 4t-furan-3-yl-1c,7t-dimethyl-(9ar)-octahydro-quinolizin-2-one; picrate (62724-11-2,62724-13-4,62724-15-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) PhLi, 2.) 4N H₂SO₄ / 1.) r.t., 3 h, 2.) r.t., 2 h

2: 76 percent / p-TsOH*H₂O / benzene / 10 h / Heating

3: 90 percent / H₂ / 5percent Rh-Al₂O₃ / acetic acid / Ambient temperature

4: 88 percent / aq. acetic acid / 17 h / 95 °C

5: 8.5 percent / 5percent aq. NaOH / methanol / 1.) r.t., 10 h, 2.) 80 deg C, 5 h

With sodium hydroxide; sulfuric acid; hydrogen; toluene-4-sulfonic acid; phenyllithium; rhodium on alumina; In methanol; acetic acid; benzene;

DOI:10.1248/cpb.28.831

Reference yield:

3-(5-methyl-2-pyridyl)butan-2-one (62740-46-9) → 4t-furan-3-yl-1c,7t-dimethyl-(9ar)-octahydro-quinolizin-2-one; picrate (62724-11-2,62724-13-4,62724-15-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 76 percent / p-TsOH*H₂O / benzene / 10 h / Heating

2: 90 percent / H₂ / 5percent Rh-Al₂O₃ / acetic acid / Ambient temperature

3: 88 percent / aq. acetic acid / 17 h / 95 °C

4: 8.5 percent / 5percent aq. NaOH / methanol / 1.) r.t., 10 h, 2.) 80 deg C, 5 h

With sodium hydroxide; hydrogen; toluene-4-sulfonic acid; rhodium on alumina; In methanol; acetic acid; benzene;

DOI:10.1248/cpb.28.831

upstream raw materials:

furan-3-carboxaldehyde

3-(5-methyl-2-piperidyl)butan-2-one

2-ethyl-5-methylpyridine

3-(5-methyl-2-pyridyl)butan-2-one

Refernces