Dexrazoxane hydrochloride

Base Information

• Chemical Name: Dexrazoxane hydrochloride
• CAS No.: 149003-01-0
• Molecular Formula: C11H16N4O4^.HCl
• Molecular Weight: 304.73
• UNII: 5346058Q7S
• DSSTox Substance ID: DTXSID60164152
• Wikidata: Q27121988
• NCI Thesaurus Code: C66945
• RXCUI: 1294534
• ChEMBL ID: CHEMBL1200778
• Mol file: 149003-01-0.mol

Synonyms:ADR 529;ADR-529;ADR529;Cardioxan;Cardioxane;Dexrazoxane;Dexrazoxane Hydrochloride;Hydrochloride, Dexrazoxane;ICRF 187;ICRF-187;ICRF187;NSC 169780;NSC-169780;NSC169780;Razoxane, (S)-Isomer;Razoxane, (S)-Isomer, Hydrochloride;Zinecard

Chemical Property of Dexrazoxane hydrochloride

Chemical Property:

• Vapor Pressure: 2.22E-11mmHg at 25°C
• Melting Point: 193oC
• Boiling Point: 531.5 °C at 760 mmHg
• Flash Point: 275.3 °C
• PSA: 98.82000
• LogP: -1.37290
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 304.0938327
• Heavy Atom Count: 20
• Complexity: 404

Purity/Quality:

99%min ^*data from raw suppliers

Dexrazoxane hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2.Cl
• Isomeric SMILES: C[C@@H](CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2.Cl
• Recent ClinicalTrials: Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia
• Recent EU Clinical Trials: A therapeutic and pharmacokinetic study of Savene (dexrazoxane) in the treatment of accidental anthracycline extravasation
• Description: Dexrazoxane hydrochloride is a cytoprotective agent which is hydrolysed to an active metabolite that chelates iron within cells.It is used (as Cardioxane) to reduce the cardiotoxicity of doxorubicin and other anthracyclines. It actively chelates iron within cells, thus preventing the formation of the anthracycline--iron complex that is thought to cause cardiotoxicity.It is also use (as Savene) in the management of anthracycline extravasation, where its action is to inhibit the enzyme topoisomerase II.
• Uses: Dexrazoxane is used to reduce the risk and severity of heart damage caused by doxorubicin treatment and similar cancer chemotherapy medications. Heart damage limits the length of time you can be treated with doxorubicin. Dexrazoxane allows you to continue doxorubicin treatment for longer. When used for this purpose, dexrazoxane treatment is usually started after you have received several doses of doxorubicin. It is usually not given with the first doses of doxorubicin since doing so may reduce the effectiveness of doxorubicin.