Diphenyl-carbamic acid 9-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-yl]-2-propionylamino-9H-purin-6-yl ester; compound with triethyl-amine

Base Information

• Chemical Name: Diphenyl-carbamic acid 9-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-yl]-2-propionylamino-9H-purin-6-yl ester; compound with triethyl-amine
• CAS No.: 113234-70-1
• Molecular Formula: C₆H₁₅N*C₅₃H₄₉N₆O₁₀PS
• Molecular Weight: 1094.24

Synonyms:

Chemical Property of Diphenyl-carbamic acid 9-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-yl]-2-propionylamino-9H-purin-6-yl ester; compound with triethyl-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of Diphenyl-carbamic acid 9-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-yl]-2-propionylamino-9H-purin-6-yl ester; compound with triethyl-amine

There total 7 articles about Diphenyl-carbamic acid 9-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-yl]-2-propionylamino-9H-purin-6-yl ester; compound with triethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → Diphenyl-carbamic acid 9-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-yl]-2-propionylamino-9H-purin-6-yl ester; compound with triethyl-amine (113234-70-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / pyridine / 0.25 h / Ambient temperature

2: 90 percent / MDS,pyridine / 8 h / Ambient temperature

3: pyridine / 0.25 h / Ambient temperature

With pyridine; In pyridine;

DOI:10.1016/S0040-4039(00)88019-3

Reference yield:

2'-Deoxyguanosine (961-07-9) → Diphenyl-carbamic acid 9-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-yl]-2-propionylamino-9H-purin-6-yl ester; compound with triethyl-amine (113234-70-1)

Guidance literature:

Multi-step reaction with 6 steps

1: N,N-dimethylaminopyridine / pyridine / 1 h / 70 °C

2: ethyldiisopropylamine / pyridine / 1 h / Ambient temperature

3: 2M NaOH / ethanol; pyridine / 0.17 h / 0 °C

4: 95 percent / pyridine / 0.25 h / Ambient temperature

5: 90 percent / MDS,pyridine / 8 h / Ambient temperature

6: pyridine / 0.25 h / Ambient temperature

With pyridine; dmap; sodium hydroxide; N-ethyl-N,N-diisopropylamine; In pyridine; ethanol;

DOI:10.1016/S0040-4039(00)88019-3

Reference yield:

Diphenyl-carbamic acid 9-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-propionylamino-9H-purin-6-yl ester (87036-65-5) → Diphenyl-carbamic acid 9-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-yl]-2-propionylamino-9H-purin-6-yl ester; compound with triethyl-amine (113234-70-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / MDS,pyridine / 8 h / Ambient temperature

2: pyridine / 0.25 h / Ambient temperature

With pyridine; In pyridine;

DOI:10.1016/S0040-4039(00)88019-3

upstream raw materials:

Diphenyl-carbamic acid 9-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(bis-phenylsulfanyl-phosphoryloxy)-tetrahydro-furan-2-yl]-2-propionylamino-9H-purin-6-yl ester

triethylamine

4,4'-dimethoxytrityl chloride

2'-Deoxyguanosine

Downstream raw materials:

C₉₁H₈₂N₁₂O₁₆P₂S₃

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