{(2S,3S,4S,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-methyl-6-[(S)-2-((1R,2R)-2-methyl-cyclopropyl)-2-triethylsilanyloxy-ethyl]-tetrahydro-pyran-2-yl}-acetic acid

Base Information

Chemical Name:{(2S,3S,4S,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-methyl-6-[(S)-2-((1R,2R)-2-methyl-cyclopropyl)-2-triethylsilanyloxy-ethyl]-tetrahydro-pyran-2-yl}-acetic acid
CAS No.:914983-50-9
Molecular Formula:C₃₆H₅₆O₅Si₂
Molecular Weight:625.009
Hs Code.:

{(2S,3S,4S,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-methyl-6-[(S)-2-((1R,2R)-2-methyl-cyclopropyl)-2-triethylsilanyloxy-ethyl]-tetrahydro-pyran-2-yl}-acetic acid

Synonyms:

Suppliers and Price of {(2S,3S,4S,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-methyl-6-[(S)-2-((1R,2R)-2-methyl-cyclopropyl)-2-triethylsilanyloxy-ethyl]-tetrahydro-pyran-2-yl}-acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of {(2S,3S,4S,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-methyl-6-[(S)-2-((1R,2R)-2-methyl-cyclopropyl)-2-triethylsilanyloxy-ethyl]-tetrahydro-pyran-2-yl}-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of {(2S,3S,4S,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-methyl-6-[(S)-2-((1R,2R)-2-methyl-cyclopropyl)-2-triethylsilanyloxy-ethyl]-tetrahydro-pyran-2-yl}-acetic acid

There total 14 articles about {(2S,3S,4S,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-methyl-6-[(S)-2-((1R,2R)-2-methyl-cyclopropyl)-2-triethylsilanyloxy-ethyl]-tetrahydro-pyran-2-yl}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: {(2S,3S,4S,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-methyl-6-[(S)-2-((1R,2R)-2-methyl-cyclopropyl)-2-triethylsilanyloxy-ethyl]-tetrahydro-pyran-2-yl}-acetaldehyde

: 914983-50-9
{(2S,3S,4S,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-methyl-6-[(S)-2-((1R,2R)-2-methyl-cyclopropyl)-2-triethylsilanyloxy-ethyl]-tetrahydro-pyran-2-yl}-acetic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In tert-butyl alcohol; at 20 ℃; for 1h;
DOI:10.1016/j.tetlet.2006.08.055

Reference yield:

: 884338-30-1
(S)-1-[(2R,4S,5S,6R)-6-Benzyloxymethyl-4-(tert-butyl-diphenyl-silanyloxy)-5-methyl-tetrahydro-pyran-2-yl]-pent-3-yn-2-ol

: 914983-50-9
{(2S,3S,4S,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-methyl-6-[(S)-2-((1R,2R)-2-methyl-cyclopropyl)-2-triethylsilanyloxy-ethyl]-tetrahydro-pyran-2-yl}-acetic acid

Guidance literature:: Multi-step reaction with 14 steps

1: Ph₃P; DEAD / tetrahydrofuran / 0.5 h / 0 - 20 °C

2: K₂CO₃ / methanol / 0.5 h / 20 °C

3: 82 percent / Red-Al / diethyl ether / 3 h / 0 - 20 °C

4: 96 percent / Et₂Zn / CH₂Cl₂ / 4 h / -20 - 0 °C

5: Dess-Martin periodinane; NaHCO₃ / CH₂Cl₂ / 0.33 h / 0 - 20 °C

6: Zn(BH₄)2 / tetrahydrofuran / 8 h / 0 °C

7: Et₃N; DMAP / CH₂Cl₂ / 1 h / 0 - 20 °C

8: H₂ / Pd/C / hexane / 1 h / 20 °C

9: Dess-Martin periodinane; NaHCO₃ / CH₂Cl₂ / 0.33 h / 0 - 20 °C

10: diethyl ether / 1 h / 0 - 20 °C

11: (cHex)2BH / tetrahydrofuran / 1 h / 0 °C

12: H₂O₂; NaOH / H₂O

13: Dess-Martin periodinane; NaHCO₃ / CH₂Cl₂ / 0.33 h / 0 - 20 °C

14: NaClO₂; NaH₂PO₄*2H₂O; 2-methyl-2-butene / 2-methyl-propan-2-ol / 1 h / 20 °C

With dmap; sodium hydroxide; sodium chlorite; sodium dihydrogenphosphate; zinc(II) tetrahydroborate; 2-methyl-but-2-ene; bis(cyclohexanyl)borane; hydrogen; dihydrogen peroxide; diethylzinc; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; triethylamine; triphenylphosphine; sodium bis(2-methoxyethoxy)aluminium dihydride; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; tert-butyl alcohol; 1: Mitsunobu reaction;
DOI:10.1016/j.tetlet.2006.08.055

Reference yield:

: 914983-44-1
(R)-1-[(2R,4S,5S,6R)-6-Benzyloxymethyl-4-(tert-butyl-diphenyl-silanyloxy)-5-methyl-tetrahydro-pyran-2-yl]-pent-3-yn-2-ol

: 914983-50-9
{(2S,3S,4S,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-methyl-6-[(S)-2-((1R,2R)-2-methyl-cyclopropyl)-2-triethylsilanyloxy-ethyl]-tetrahydro-pyran-2-yl}-acetic acid

Guidance literature:: Multi-step reaction with 12 steps

1: 82 percent / Red-Al / diethyl ether / 3 h / 0 - 20 °C

2: 96 percent / Et₂Zn / CH₂Cl₂ / 4 h / -20 - 0 °C

3: Dess-Martin periodinane; NaHCO₃ / CH₂Cl₂ / 0.33 h / 0 - 20 °C

4: Zn(BH₄)2 / tetrahydrofuran / 8 h / 0 °C

5: Et₃N; DMAP / CH₂Cl₂ / 1 h / 0 - 20 °C

6: H₂ / Pd/C / hexane / 1 h / 20 °C

7: Dess-Martin periodinane; NaHCO₃ / CH₂Cl₂ / 0.33 h / 0 - 20 °C

8: diethyl ether / 1 h / 0 - 20 °C

9: (cHex)2BH / tetrahydrofuran / 1 h / 0 °C

10: H₂O₂; NaOH / H₂O

11: Dess-Martin periodinane; NaHCO₃ / CH₂Cl₂ / 0.33 h / 0 - 20 °C

12: NaClO₂; NaH₂PO₄*2H₂O; 2-methyl-2-butene / 2-methyl-propan-2-ol / 1 h / 20 °C

With dmap; sodium hydroxide; sodium chlorite; sodium dihydrogenphosphate; zinc(II) tetrahydroborate; 2-methyl-but-2-ene; bis(cyclohexanyl)borane; hydrogen; dihydrogen peroxide; diethylzinc; sodium hydrogencarbonate; Dess-Martin periodane; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/j.tetlet.2006.08.055