4-Nitro-benzoic acid (2S,3S,4S,6R)-6-((1S,3R)-3-acetyl-3-fluoro-5,12-dihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-1-yloxy)-4-allyloxycarbonylamino-2-methyl-tetrahydro-pyran-3-yl ester

Base Information

Chemical Name:4-Nitro-benzoic acid (2S,3S,4S,6R)-6-((1S,3R)-3-acetyl-3-fluoro-5,12-dihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-1-yloxy)-4-allyloxycarbonylamino-2-methyl-tetrahydro-pyran-3-yl ester
CAS No.:207394-54-5
Molecular Formula:C₃₇H₃₃FN₂O₁₃
Molecular Weight:732.673
Hs Code.:

4-Nitro-benzoic acid (2S,3S,4S,6R)-6-((1S,3R)-3-acetyl-3-fluoro-5,12-dihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-1-yloxy)-4-allyloxycarbonylamino-2-methyl-tetrahydro-pyran-3-yl ester

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Chemical Property of 4-Nitro-benzoic acid (2S,3S,4S,6R)-6-((1S,3R)-3-acetyl-3-fluoro-5,12-dihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-1-yloxy)-4-allyloxycarbonylamino-2-methyl-tetrahydro-pyran-3-yl ester

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Technology Process of 4-Nitro-benzoic acid (2S,3S,4S,6R)-6-((1S,3R)-3-acetyl-3-fluoro-5,12-dihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-1-yloxy)-4-allyloxycarbonylamino-2-methyl-tetrahydro-pyran-3-yl ester

There total 4 articles about 4-Nitro-benzoic acid (2S,3S,4S,6R)-6-((1S,3R)-3-acetyl-3-fluoro-5,12-dihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-1-yloxy)-4-allyloxycarbonylamino-2-methyl-tetrahydro-pyran-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 196512-07-9
3-N-allyloxycarbonyl-1,4-di-O-p-nitrobenzoyl-3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranose

: (7R,9S)-9-Acetyl-9-fluoro-6,7,11-trihydroxy-7,8,9,10-tetrahydro-naphthacene-5,12-dione

: 207394-54-5
4-Nitro-benzoic acid (2S,3S,4S,6R)-6-((1S,3R)-3-acetyl-3-fluoro-5,12-dihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-1-yloxy)-4-allyloxycarbonylamino-2-methyl-tetrahydro-pyran-3-yl ester

: 207394-55-6
4-Nitro-benzoic acid (2S,3S,4S,6R)-6-((1R,3S)-3-acetyl-3-fluoro-5,12-dihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-1-yloxy)-4-allyloxycarbonylamino-2-methyl-tetrahydro-pyran-3-yl ester

Guidance literature:: With molecular sieve; trimethylsilyl trifluoromethanesulfonate; In diethyl ether; dichloromethane; at -5 ℃; for 3h;

Reference yield:

: 89074-03-3
9-(1-hydroxyethyl)-7,10-dihydro-6,11-dihydroxy-5,12-naphthacenedione

: 207394-54-5
4-Nitro-benzoic acid (2S,3S,4S,6R)-6-((1S,3R)-3-acetyl-3-fluoro-5,12-dihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-1-yloxy)-4-allyloxycarbonylamino-2-methyl-tetrahydro-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NBS, HF-pyridine; 2.) Bu₃SnH, AIBN / 1.) CH₂Cl₂, 0 deg C, 4 h; 2.) toluene, 120 deg C, 40 h

2: 43 percent / Dess-Martin reagent / CH₂Cl₂ / 24 h / Ambient temperature

3: 1.) polymer pyridinium hydrobromide perbromite, AIBN; 2.) TFA / 1.) CCl₄, 110 deg C, 5 h; 2.) H₂O, 110 deg C, 2 h

4: TMSOTf, molecular sieves / CH₂Cl₂; diethyl ether / 3 h / -5 °C

With N-Bromosuccinimide; molecular sieve; 2,2'-azobis(isobutyronitrile); trimethylsilyl trifluoromethanesulfonate; polymer pyridinium hydrobromide perbromite; tri-n-butyl-tin hydride; Dess-Martin periodane; pyridine hydrogenfluoride; trifluoroacetic acid; In diethyl ether; dichloromethane;

Reference yield:

: 8-Acetyl-8-fluoro-6,11-dihydroxy-7,8,9,10-tetrahydro-naphthacene-5,12-dione

: 207394-54-5
4-Nitro-benzoic acid (2S,3S,4S,6R)-6-((1S,3R)-3-acetyl-3-fluoro-5,12-dihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-1-yloxy)-4-allyloxycarbonylamino-2-methyl-tetrahydro-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) polymer pyridinium hydrobromide perbromite, AIBN; 2.) TFA / 1.) CCl₄, 110 deg C, 5 h; 2.) H₂O, 110 deg C, 2 h

2: TMSOTf, molecular sieves / CH₂Cl₂; diethyl ether / 3 h / -5 °C

With molecular sieve; 2,2'-azobis(isobutyronitrile); trimethylsilyl trifluoromethanesulfonate; polymer pyridinium hydrobromide perbromite; trifluoroacetic acid; In diethyl ether; dichloromethane;