5-<4-(3-aminopropionylamino)benzyl>thiazolidine-2,4-dione hydrobromide

Base Information

Chemical Name:5-<4-(3-aminopropionylamino)benzyl>thiazolidine-2,4-dione hydrobromide
CAS No.:85002-40-0
Molecular Formula:BrH*C₁₃H₁₅N₃O₃S
Molecular Weight:374.258
Hs Code.:

Synonyms:

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Chemical Property of 5-<4-(3-aminopropionylamino)benzyl>thiazolidine-2,4-dione hydrobromide

Chemical Property:

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Technology Process of 5-<4-(3-aminopropionylamino)benzyl>thiazolidine-2,4-dione hydrobromide

There total 4 articles about 5-<4-(3-aminopropionylamino)benzyl>thiazolidine-2,4-dione hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 57460-34-1
ethyl 2-chloro-3-(4-nitrophenyl)propionate

: 85002-40-0
5-<4-(3-aminopropionylamino)benzyl>thiazolidine-2,4-dione hydrobromide

Guidance literature:: Multi-step reaction with 4 steps

1: 2.) 2N HCl / 1.) sulfolane, 120 deg C, 5 h; 2.) sulfolane, 100 deg C, 15 h

2: 88.6 percent / hydrogen / 10percent Pd-C / methanol; ethyl acetate / 760 Torr / Ambient temperature

3: 1.) Et₃N, ethyl chloroformate; 2.) Et₃N / 1.) ice-cooling, 15 min; 2.) CH₂Cl₂, room temp., overnight

4: 61.4 percent / HBr / acetic acid / 0.5 h / Ambient temperature

With hydrogenchloride; hydrogen bromide; hydrogen; chloroformic acid ethyl ester; triethylamine; palladium on activated charcoal; In methanol; acetic acid; ethyl acetate;
DOI:10.1248/cpb.30.3580

Reference yield:

: 100-01-6,104810-17-5
4-nitro-aniline

: 85002-40-0
5-<4-(3-aminopropionylamino)benzyl>thiazolidine-2,4-dione hydrobromide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaNO₂, conc. HCl, 2.) Cu₂O / 1.) acetone, water, 5 deg C, 30 min, 2.) acetone, water, 10 deg C

2: 2.) 2N HCl / 1.) sulfolane, 120 deg C, 5 h; 2.) sulfolane, 100 deg C, 15 h

3: 88.6 percent / hydrogen / 10percent Pd-C / methanol; ethyl acetate / 760 Torr / Ambient temperature

4: 1.) Et₃N, ethyl chloroformate; 2.) Et₃N / 1.) ice-cooling, 15 min; 2.) CH₂Cl₂, room temp., overnight

5: 61.4 percent / HBr / acetic acid / 0.5 h / Ambient temperature

With copper(I) oxide; hydrogenchloride; hydrogen bromide; hydrogen; chloroformic acid ethyl ester; triethylamine; sodium nitrite; palladium on activated charcoal; In methanol; acetic acid; ethyl acetate;
DOI:10.1248/cpb.30.3580

Reference yield:

: 85003-57-2
5-(4-nitrobenzyl)-1,3-thiazolidine-2,4-dione

: 85002-40-0
5-<4-(3-aminopropionylamino)benzyl>thiazolidine-2,4-dione hydrobromide

Guidance literature:: Multi-step reaction with 3 steps

1: 88.6 percent / hydrogen / 10percent Pd-C / methanol; ethyl acetate / 760 Torr / Ambient temperature

2: 1.) Et₃N, ethyl chloroformate; 2.) Et₃N / 1.) ice-cooling, 15 min; 2.) CH₂Cl₂, room temp., overnight

3: 61.4 percent / HBr / acetic acid / 0.5 h / Ambient temperature

With hydrogen bromide; hydrogen; chloroformic acid ethyl ester; triethylamine; palladium on activated charcoal; In methanol; acetic acid; ethyl acetate;
DOI:10.1248/cpb.30.3580