[(1S,2S,4R)-1,4-Dibenzyl-5-((3aS,8aR)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-2-hydroxy-5-oxo-pentyl]-carbamic acid tert-butyl ester

Base Information

• Chemical Name: [(1S,2S,4R)-1,4-Dibenzyl-5-((3aS,8aR)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-2-hydroxy-5-oxo-pentyl]-carbamic acid tert-butyl ester
• CAS No.: 141018-42-0
• Molecular Formula: C₃₆H₄₄N₂O₅
• Molecular Weight: 584.756

Synonyms:

Chemical Property of [(1S,2S,4R)-1,4-Dibenzyl-5-((3aS,8aR)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-2-hydroxy-5-oxo-pentyl]-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of [(1S,2S,4R)-1,4-Dibenzyl-5-((3aS,8aR)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-2-hydroxy-5-oxo-pentyl]-carbamic acid tert-butyl ester

There total 1 articles about [(1S,2S,4R)-1,4-Dibenzyl-5-((3aS,8aR)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-2-hydroxy-5-oxo-pentyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane (98760-08-8) + (3aS,8aR)-2,2-dimethyl-3-(3-phenylpropanoyl)-3,3a,8,8a-tetrahydro-2H-indeno[1,2-d][1,3]oxazole (141018-37-3) → [(1S,2S,4R)-1,4-Dibenzyl-5-((3aS,8aR)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-2-hydroxy-5-oxo-pentyl]-carbamic acid tert-butyl ester (141018-42-0)

Guidance literature:

With n-butyllithium; for 2h; Yield given; -78 to -25 deg C;

DOI:10.1021/jo00036a004

Reference yield:

[(1S,2S,4R)-1,4-Dibenzyl-5-((3aS,8aR)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-2-hydroxy-5-oxo-pentyl]-carbamic acid tert-butyl ester (141018-42-0) → [(1S,2S,4R)-1-Benzyl-2-hydroxy-4-(3H-inden-1-ylcarbamoyl)-5-phenyl-pentyl]-carbamic acid tert-butyl ester

Guidance literature:

With n-butyllithium; at -78 ℃;

DOI:10.1021/jo00036a004

Reference yield:

[(1S,2S,4R)-1,4-Dibenzyl-5-((3aS,8aR)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-2-hydroxy-5-oxo-pentyl]-carbamic acid tert-butyl ester (141018-42-0) → L-685434 (126456-36-8)

Guidance literature:

With methanol; camphor-10-sulfonic acid;

DOI:10.1021/jo00036a004

upstream raw materials:

(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane

(3aS,8aR)-2,2-dimethyl-3-(3-phenylpropanoyl)-3,3a,8,8a-tetrahydro-2H-indeno[1,2-d][1,3]oxazole

Downstream raw materials:

L-685434

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