((S)-1-{(S)-2-(1H-Imidazol-4-yl)-1-[(S)-3-methyl-1-(2-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-acetyl)-butylcarbamoyl]-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:((S)-1-{(S)-2-(1H-Imidazol-4-yl)-1-[(S)-3-methyl-1-(2-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-acetyl)-butylcarbamoyl]-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester
CAS No.:97920-13-3
Molecular Formula:C₄₀H₅₆N₈O₇
Molecular Weight:760.934
Hs Code.:

((S)-1-{(S)-2-(1H-Imidazol-4-yl)-1-[(S)-3-methyl-1-(2-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-acetyl)-butylcarbamoyl]-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

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Chemical Property of ((S)-1-{(S)-2-(1H-Imidazol-4-yl)-1-[(S)-3-methyl-1-(2-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-acetyl)-butylcarbamoyl]-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

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Technology Process of ((S)-1-{(S)-2-(1H-Imidazol-4-yl)-1-[(S)-3-methyl-1-(2-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-acetyl)-butylcarbamoyl]-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

There total 12 articles about ((S)-1-{(S)-2-(1H-Imidazol-4-yl)-1-[(S)-3-methyl-1-(2-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-acetyl)-butylcarbamoyl]-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ((S)-1-{(S)-1-[(S)-3-Methyl-1-(2-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-acetyl)-butylcarbamoyl]-2-[1-(toluene-4-sulfonyl)-1H-imidazol-4-yl]-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

: 97920-13-3
((S)-1-{(S)-2-(1H-Imidazol-4-yl)-1-[(S)-3-methyl-1-(2-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-acetyl)-butylcarbamoyl]-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; In methanol; for 15h; Ambient temperature;
DOI:10.1021/jm00160a048

Reference yield:

: 3731-51-9
2-(Aminomethyl)pyridine

: 97920-13-3
((S)-1-{(S)-2-(1H-Imidazol-4-yl)-1-[(S)-3-methyl-1-(2-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-acetyl)-butylcarbamoyl]-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 88 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / CH₂Cl₂ / 14 h / Ambient temperature

2: 100 percent / CF₃COOH / CH₂Cl₂ / 1 h / Ambient temperature

3: 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / CH₂Cl₂ / 48 h

4: CF₃COOH / CH₂Cl₂ / 1 h / Ambient temperature

5: Et₃N, diethylphosphoryl cyanide / CH₂Cl₂ / 15 h

6: CF₃COOH / CH₂Cl₂ / 1 h / Ambient temperature

7: Et₃N, diethylphosphoryl cyanide / CH₂Cl₂

8: oxalyl chloride, dimethyl sulfoxide / CH₂Cl₂ / 1 h / -20 °C

9: 1-hydroxybenzotriazole / methanol / 15 h / Ambient temperature

With diethylphosphoryl cyanide; oxalyl dichloride; benzotriazol-1-ol; dimethyl sulfoxide; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1021/jm00160a048

Reference yield:

: 13139-16-7
N-(tert-butyloxycarbonyl)-L-isoleucine

: 97920-13-3
((S)-1-{(S)-2-(1H-Imidazol-4-yl)-1-[(S)-3-methyl-1-(2-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-acetyl)-butylcarbamoyl]-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 88 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / CH₂Cl₂ / 14 h / Ambient temperature

2: 100 percent / CF₃COOH / CH₂Cl₂ / 1 h / Ambient temperature

3: 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / CH₂Cl₂ / 48 h

4: CF₃COOH / CH₂Cl₂ / 1 h / Ambient temperature

5: Et₃N, diethylphosphoryl cyanide / CH₂Cl₂ / 15 h

6: CF₃COOH / CH₂Cl₂ / 1 h / Ambient temperature

7: Et₃N, diethylphosphoryl cyanide / CH₂Cl₂

8: oxalyl chloride, dimethyl sulfoxide / CH₂Cl₂ / 1 h / -20 °C

9: 1-hydroxybenzotriazole / methanol / 15 h / Ambient temperature

With diethylphosphoryl cyanide; oxalyl dichloride; benzotriazol-1-ol; dimethyl sulfoxide; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1021/jm00160a048