2-Chloro-3-(4-cyclopropylmethoxy-phenyl)-propionic acid methyl ester

Base Information

• Chemical Name: 2-Chloro-3-(4-cyclopropylmethoxy-phenyl)-propionic acid methyl ester
• CAS No.: 85003-34-5
• Molecular Formula: C₁₄H₁₇ClO₃
• Molecular Weight: 268.74
• Mol file: 85003-34-5.mol

Synonyms:

Chemical Property of 2-Chloro-3-(4-cyclopropylmethoxy-phenyl)-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Chloro-3-(4-cyclopropylmethoxy-phenyl)-propionic acid methyl ester

There total 2 articles about 2-Chloro-3-(4-cyclopropylmethoxy-phenyl)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-{(cyclopropyl)methoxy}-4-nitrobenzene (85002-74-0) → 2-Chloro-3-(4-cyclopropylmethoxy-phenyl)-propionic acid methyl ester (85003-34-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / 10percent Pd-C / methanol / 760 Torr / Ambient temperature

2: 1.) NaNO₂, conc. HCl, 2.) Cu₂O / 1.) acetone, water, 5 deg C, 30 min, 2.) acetone, water, 35 deg C

With copper(I) oxide; hydrogenchloride; hydrogen; sodium nitrite; palladium on activated charcoal; In methanol;

DOI:10.1248/cpb.30.3580

Reference yield:

4-Fluoronitrobenzene (350-46-9,178603-76-4) → 2-Chloro-3-(4-cyclopropylmethoxy-phenyl)-propionic acid methyl ester (85003-34-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 78.1 percent / NaH / dimethylformamide / 1 h / 0 °C

2: hydrogen / 10percent Pd-C / methanol / 760 Torr / Ambient temperature

3: 1.) NaNO₂, conc. HCl, 2.) Cu₂O / 1.) acetone, water, 5 deg C, 30 min, 2.) acetone, water, 35 deg C

With copper(I) oxide; hydrogenchloride; hydrogen; sodium hydride; sodium nitrite; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.30.3580

Reference yield:

2-Chloro-3-(4-cyclopropylmethoxy-phenyl)-propionic acid methyl ester (85003-34-5) + thiourea (17356-08-0) → 5-(4-Cyclopropylmethoxy-benzyl)-thiazolidine-2,4-dione (74773-28-7)

Guidance literature:

With hydrogenchloride; Yield given. Multistep reaction; 1.) sulfolane, 120 deg C, 10 h; 2.) sulfolane, 100 deg C, 8 h;

DOI:10.1248/cpb.30.3580

upstream raw materials:

1-{(cyclopropyl)methoxy}-4-nitrobenzene

4-Fluoronitrobenzene

Downstream raw materials:

5-(4-Cyclopropylmethoxy-benzyl)-thiazolidine-2,4-dione

Refernces