[4-(Cyclohexyl-methyl-amino)-1-ethyl-1,2,3,4-tetrahydro-quinolin-8-yl]-methanol

Base Information

Chemical Name:[4-(Cyclohexyl-methyl-amino)-1-ethyl-1,2,3,4-tetrahydro-quinolin-8-yl]-methanol
CAS No.:130020-41-6
Molecular Formula:C₁₉H₃₀N₂O
Molecular Weight:302.46
Hs Code.:

Synonyms:

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Chemical Property of [4-(Cyclohexyl-methyl-amino)-1-ethyl-1,2,3,4-tetrahydro-quinolin-8-yl]-methanol

Chemical Property:

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Technology Process of [4-(Cyclohexyl-methyl-amino)-1-ethyl-1,2,3,4-tetrahydro-quinolin-8-yl]-methanol

There total 12 articles about [4-(Cyclohexyl-methyl-amino)-1-ethyl-1,2,3,4-tetrahydro-quinolin-8-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-Cyclohexyl-N-(1-ethyl-8-hydroxymethyl-1,2,3,4-tetrahydro-quinolin-4-yl)-formamide

: 130020-41-6
[4-(Cyclohexyl-methyl-amino)-1-ethyl-1,2,3,4-tetrahydro-quinolin-8-yl]-methanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; Yield given; Heating;
DOI:10.1248/cpb.38.1575

Reference yield:

: 5344-90-1
2-Aminobenzyl alcohol

: 130020-41-6
[4-(Cyclohexyl-methyl-amino)-1-ethyl-1,2,3,4-tetrahydro-quinolin-8-yl]-methanol

Guidance literature:: Multi-step reaction with 12 steps

1: 74 percent / Et₃N / tetrahydrofuran / 2 h / Ambient temperature

2: 90 percent / K₂CO₃ / dimethylformamide / 5 h / 50 °C

3: 92 percent / Na₂CO₃ / methanol / 8 h / Heating

4: 60 percent / polyphosphoric acid / 1 h / 120 °C

5: 72 percent / p-TsOH / toluene / 3 h / Heating

6: 61 percent / NaOH / methanol / 5 h / Heating

8: 98 percent / 10percent HCl / tetrahydrofuran / Ambient temperature

9: molecular sieves 3A, p-TsOH / methanol / 65 °C

10: NaBH₄ / methanol / Ambient temperature

11: acetic anhydride / Ambient temperature

12: LiAlH₄ / tetrahydrofuran / Heating

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; PPA; 3 A molecular sieve; acetic anhydride; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.38.1575

Reference yield:

: 13213-88-2
1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one

: 130020-41-6
[4-(Cyclohexyl-methyl-amino)-1-ethyl-1,2,3,4-tetrahydro-quinolin-8-yl]-methanol

Guidance literature:: Multi-step reaction with 11 steps

1: 90 percent / K₂CO₃ / dimethylformamide / 5 h / 50 °C

2: 92 percent / Na₂CO₃ / methanol / 8 h / Heating

3: 60 percent / polyphosphoric acid / 1 h / 120 °C

4: 72 percent / p-TsOH / toluene / 3 h / Heating

5: 61 percent / NaOH / methanol / 5 h / Heating

7: 98 percent / 10percent HCl / tetrahydrofuran / Ambient temperature

8: molecular sieves 3A, p-TsOH / methanol / 65 °C

9: NaBH₄ / methanol / Ambient temperature

10: acetic anhydride / Ambient temperature

11: LiAlH₄ / tetrahydrofuran / Heating

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; PPA; 3 A molecular sieve; acetic anhydride; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.38.1575