tert-butyl (2-[3-({12-[(tert-butoxycarbonyl)amino]dodecyl}amino)-3-oxopropyl]-4-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}phenoxy)acetate

Base Information

Chemical Name:tert-butyl (2-[3-({12-[(tert-butoxycarbonyl)amino]dodecyl}amino)-3-oxopropyl]-4-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}phenoxy)acetate
CAS No.:1355027-78-9
Molecular Formula:C₄₉H₇₁N₅O₈
Molecular Weight:858.131
Hs Code.:

tert-butyl (2-[3-({12-[(tert-butoxycarbonyl)amino]dodecyl}amino)-3-oxopropyl]-4-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}phenoxy)acetate

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Chemical Property of tert-butyl (2-[3-({12-[(tert-butoxycarbonyl)amino]dodecyl}amino)-3-oxopropyl]-4-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}phenoxy)acetate

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Technology Process of tert-butyl (2-[3-({12-[(tert-butoxycarbonyl)amino]dodecyl}amino)-3-oxopropyl]-4-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}phenoxy)acetate

There total 9 articles about tert-butyl (2-[3-({12-[(tert-butoxycarbonyl)amino]dodecyl}amino)-3-oxopropyl]-4-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}phenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1016274-45-5
C₁₀H₁₃NO₃

: 1355027-78-9
tert-butyl (2-[3-({12-[(tert-butoxycarbonyl)amino]dodecyl}amino)-3-oxopropyl]-4-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}phenoxy)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide

2: sulfuric acid / acetonitrile / 60 °C

3: caesium carbonate / N,N-dimethyl-formamide

4: palladium 10% on activated carbon; hydrogen / ethanol; N,N-dimethyl-formamide

5: 1-[(1-(cyano-?2-?ethoxy-?2-?oxoethylidenaminooxy)?dimethylamino-?morpholino)]-uronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

With 1-[(1-(cyano-?2-?ethoxy-?2-?oxoethylidenaminooxy)?dimethylamino-?morpholino)]-uronium hexafluorophosphate; sulfuric acid; palladium 10% on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2011.10.078

Reference yield:

: 1355027-77-8
C₃₉H₄₃N₃O₇

: 1355027-78-9
tert-butyl (2-[3-({12-[(tert-butoxycarbonyl)amino]dodecyl}amino)-3-oxopropyl]-4-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}phenoxy)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol; N,N-dimethyl-formamide

2: 1-[(1-(cyano-?2-?ethoxy-?2-?oxoethylidenaminooxy)?dimethylamino-?morpholino)]-uronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

With 1-[(1-(cyano-?2-?ethoxy-?2-?oxoethylidenaminooxy)?dimethylamino-?morpholino)]-uronium hexafluorophosphate; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.10.078

Reference yield:

: 1355027-76-7
C₃₃H₃₃N₃O₅

: 1355027-78-9
tert-butyl (2-[3-({12-[(tert-butoxycarbonyl)amino]dodecyl}amino)-3-oxopropyl]-4-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}phenoxy)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide

2: palladium 10% on activated carbon; hydrogen / ethanol; N,N-dimethyl-formamide

3: 1-[(1-(cyano-?2-?ethoxy-?2-?oxoethylidenaminooxy)?dimethylamino-?morpholino)]-uronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

With 1-[(1-(cyano-?2-?ethoxy-?2-?oxoethylidenaminooxy)?dimethylamino-?morpholino)]-uronium hexafluorophosphate; palladium 10% on activated carbon; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.10.078