(4R,5R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-[(E)-(S)-1-(tert-butyl-diphenyl-silanyloxy)-4-(2-trimethylsilanyl-ethoxymethoxy)-but-2-enyl]-2,2-dimethyl-[1,3]dioxolane

Base Information

Chemical Name:(4R,5R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-[(E)-(S)-1-(tert-butyl-diphenyl-silanyloxy)-4-(2-trimethylsilanyl-ethoxymethoxy)-but-2-enyl]-2,2-dimethyl-[1,3]dioxolane
CAS No.:875303-39-2
Molecular Formula:C₃₈H₆₄O₆Si₃
Molecular Weight:701.179
Hs Code.:

(4R,5R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-[(E)-(S)-1-(tert-butyl-diphenyl-silanyloxy)-4-(2-trimethylsilanyl-ethoxymethoxy)-but-2-enyl]-2,2-dimethyl-[1,3]dioxolane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R,5R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-[(E)-(S)-1-(tert-butyl-diphenyl-silanyloxy)-4-(2-trimethylsilanyl-ethoxymethoxy)-but-2-enyl]-2,2-dimethyl-[1,3]dioxolane

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Technology Process of (4R,5R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-[(E)-(S)-1-(tert-butyl-diphenyl-silanyloxy)-4-(2-trimethylsilanyl-ethoxymethoxy)-but-2-enyl]-2,2-dimethyl-[1,3]dioxolane

There total 5 articles about (4R,5R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-[(E)-(S)-1-(tert-butyl-diphenyl-silanyloxy)-4-(2-trimethylsilanyl-ethoxymethoxy)-but-2-enyl]-2,2-dimethyl-[1,3]dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 875303-38-1
(E)-(S)-4-[(4R,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-4-(tert-butyl-diphenyl-silanyloxy)-but-2-en-1-ol

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 875303-39-2
(4R,5R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-[(E)-(S)-1-(tert-butyl-diphenyl-silanyloxy)-4-(2-trimethylsilanyl-ethoxymethoxy)-but-2-enyl]-2,2-dimethyl-[1,3]dioxolane

Guidance literature:: With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine;
DOI:10.1055/s-2005-918960

Reference yield:

: 875303-35-8
(E)-(S)-4-Hydroxy-4-((4S,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-2-enoic acid tert-butyl ester

: 875303-39-2
(4R,5R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-[(E)-(S)-1-(tert-butyl-diphenyl-silanyloxy)-4-(2-trimethylsilanyl-ethoxymethoxy)-but-2-enyl]-2,2-dimethyl-[1,3]dioxolane

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / Et₃N; DMAP

2: 100 percent / imidazole; DMAP / dimethylformamide / 50 °C

3: 95 percent / DIBAL-H; NaBH₄ / CH₂Cl₂; tetrahydrofuran; methanol

4: 99 percent / i-Pr₂NEt; Bu₄NI

With 1H-imidazole; dmap; sodium tetrahydroborate; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-2005-918960

Reference yield:

: 875303-36-9
(E)-(S)-4-[(4S,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-4-hydroxy-but-2-enoic acid tert-butyl ester

: 875303-39-2
(4R,5R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-[(E)-(S)-1-(tert-butyl-diphenyl-silanyloxy)-4-(2-trimethylsilanyl-ethoxymethoxy)-but-2-enyl]-2,2-dimethyl-[1,3]dioxolane

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / imidazole; DMAP / dimethylformamide / 50 °C

2: 95 percent / DIBAL-H; NaBH₄ / CH₂Cl₂; tetrahydrofuran; methanol

3: 99 percent / i-Pr₂NEt; Bu₄NI

With 1H-imidazole; dmap; sodium tetrahydroborate; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-2005-918960