(3S,4R,4aR,6S,6aS,12aR,12bS)-9-(3,4-Dimethoxy-phenyl)-3,6-dihydroxy-4-hydroxymethyl-4,6a,12b-trimethyl-1,2,3,4,4a,5,6,6a,12a,12b-decahydro-7,10-dioxa-benzo[a]anthracene-11,12-dione

Base Information

Chemical Name:(3S,4R,4aR,6S,6aS,12aR,12bS)-9-(3,4-Dimethoxy-phenyl)-3,6-dihydroxy-4-hydroxymethyl-4,6a,12b-trimethyl-1,2,3,4,4a,5,6,6a,12a,12b-decahydro-7,10-dioxa-benzo[a]anthracene-11,12-dione
CAS No.:290816-24-9
Molecular Formula:C₂₈H₃₄O₉
Molecular Weight:514.573
Hs Code.:

(3S,4R,4aR,6S,6aS,12aR,12bS)-9-(3,4-Dimethoxy-phenyl)-3,6-dihydroxy-4-hydroxymethyl-4,6a,12b-trimethyl-1,2,3,4,4a,5,6,6a,12a,12b-decahydro-7,10-dioxa-benzo[a]anthracene-11,12-dione

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Suppliers and Price of (3S,4R,4aR,6S,6aS,12aR,12bS)-9-(3,4-Dimethoxy-phenyl)-3,6-dihydroxy-4-hydroxymethyl-4,6a,12b-trimethyl-1,2,3,4,4a,5,6,6a,12a,12b-decahydro-7,10-dioxa-benzo[a]anthracene-11,12-dione

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Chemical Property of (3S,4R,4aR,6S,6aS,12aR,12bS)-9-(3,4-Dimethoxy-phenyl)-3,6-dihydroxy-4-hydroxymethyl-4,6a,12b-trimethyl-1,2,3,4,4a,5,6,6a,12a,12b-decahydro-7,10-dioxa-benzo[a]anthracene-11,12-dione

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Technology Process of (3S,4R,4aR,6S,6aS,12aR,12bS)-9-(3,4-Dimethoxy-phenyl)-3,6-dihydroxy-4-hydroxymethyl-4,6a,12b-trimethyl-1,2,3,4,4a,5,6,6a,12a,12b-decahydro-7,10-dioxa-benzo[a]anthracene-11,12-dione

There total 3 articles about (3S,4R,4aR,6S,6aS,12aR,12bS)-9-(3,4-Dimethoxy-phenyl)-3,6-dihydroxy-4-hydroxymethyl-4,6a,12b-trimethyl-1,2,3,4,4a,5,6,6a,12a,12b-decahydro-7,10-dioxa-benzo[a]anthracene-11,12-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 171925-86-3
Acetic acid (3S,4R,4aR,6S,6aS,12aR,12bS)-3-acetoxy-4-acetoxymethyl-4,6a,12b-trimethyl-11,12-dioxo-9-pyridin-3-yl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-7,10-dioxa-benzo[a]anthracen-6-yl ester

: 290816-24-9
(3S,4R,4aR,6S,6aS,12aR,12bS)-9-(3,4-Dimethoxy-phenyl)-3,6-dihydroxy-4-hydroxymethyl-4,6a,12b-trimethyl-1,2,3,4,4a,5,6,6a,12a,12b-decahydro-7,10-dioxa-benzo[a]anthracene-11,12-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / MeONa / H₂O / 17 h / Ambient temperature

2: 90 percent / 2,6-lutidine / CH₂Cl₂ / 0.33 h / Ambient temperature

3: 1.) LiHMDS, TMEDA / tetrahydrofuran / 1.) 0 deg C, 0.5 h, then room temp., 1.5 h; 2.) 0 deg C

4: tetrahydrofuran / 0 deg C, 0.5 h, then room temp., 1.5 h

5: tributylammonium fluoride / tetrahydrofuran / 17 h / Ambient temperature

With 2,6-dimethylpyridine; N,N,N,N,-tetramethylethylenediamine; sodium methylate; tri-n-butylamine hydrofluoride; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water;
DOI:10.1246/cl.1997.935

Reference yield:

: 172704-62-0
(4aS,5S,6aR,7R,8S,10aS,10bR)-5,8-Dihydroxy-7-hydroxymethyl-3,4a,7,10a-tetramethyl-1-oxo-4a,5,6,6a,7,8,9,10,10a,10b-decahydro-1H-benzo[f]chromene-2-carboxylic acid methyl ester

: 290816-24-9
(3S,4R,4aR,6S,6aS,12aR,12bS)-9-(3,4-Dimethoxy-phenyl)-3,6-dihydroxy-4-hydroxymethyl-4,6a,12b-trimethyl-1,2,3,4,4a,5,6,6a,12a,12b-decahydro-7,10-dioxa-benzo[a]anthracene-11,12-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / 2,6-lutidine / CH₂Cl₂ / 0.33 h / Ambient temperature

2: 1.) LiHMDS, TMEDA / tetrahydrofuran / 1.) 0 deg C, 0.5 h, then room temp., 1.5 h; 2.) 0 deg C

3: tetrahydrofuran / 0 deg C, 0.5 h, then room temp., 1.5 h

4: tributylammonium fluoride / tetrahydrofuran / 17 h / Ambient temperature

With 2,6-dimethylpyridine; N,N,N,N,-tetramethylethylenediamine; tri-n-butylamine hydrofluoride; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1246/cl.1997.935

Reference yield:

: (4aS,5S,6aR,7R,8S,10aS,10bR)-3-[2-(3,4-Dimethoxy-phenyl)-2-oxo-ethyl]-4a,7,10a-trimethyl-1-oxo-5,8-bis-trimethylsilanyloxy-7-trimethylsilanyloxymethyl-4a,5,6,6a,7,8,9,10,10a,10b-decahydro-1H-benzo[f]chromene-2-carboxylic acid methyl ester

: 290816-24-9
(3S,4R,4aR,6S,6aS,12aR,12bS)-9-(3,4-Dimethoxy-phenyl)-3,6-dihydroxy-4-hydroxymethyl-4,6a,12b-trimethyl-1,2,3,4,4a,5,6,6a,12a,12b-decahydro-7,10-dioxa-benzo[a]anthracene-11,12-dione

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 0 deg C, 0.5 h, then room temp., 1.5 h

2: tributylammonium fluoride / tetrahydrofuran / 17 h / Ambient temperature

With tri-n-butylamine hydrofluoride; In tetrahydrofuran;
DOI:10.1246/cl.1997.935