N-{4-[4-(4-amino-3,5-dimethyl-phenyl)-1-(3,4,5-tris-tetradecyloxy-benzoyl)-piperidin-4-yl]-2,6-dimethyl-phenyl}-2,6,N-trimethyl-4-nitro-benzamide

Base Information

Chemical Name:N-{4-[4-(4-amino-3,5-dimethyl-phenyl)-1-(3,4,5-tris-tetradecyloxy-benzoyl)-piperidin-4-yl]-2,6-dimethyl-phenyl}-2,6,N-trimethyl-4-nitro-benzamide
CAS No.:936027-43-9
Molecular Formula:C₈₀H₁₂₆N₄O₇
Molecular Weight:1255.9
Hs Code.:

N-{4-[4-(4-amino-3,5-dimethyl-phenyl)-1-(3,4,5-tris-tetradecyloxy-benzoyl)-piperidin-4-yl]-2,6-dimethyl-phenyl}-2,6,N-trimethyl-4-nitro-benzamide

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Chemical Property of N-{4-[4-(4-amino-3,5-dimethyl-phenyl)-1-(3,4,5-tris-tetradecyloxy-benzoyl)-piperidin-4-yl]-2,6-dimethyl-phenyl}-2,6,N-trimethyl-4-nitro-benzamide

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Technology Process of N-{4-[4-(4-amino-3,5-dimethyl-phenyl)-1-(3,4,5-tris-tetradecyloxy-benzoyl)-piperidin-4-yl]-2,6-dimethyl-phenyl}-2,6,N-trimethyl-4-nitro-benzamide

There total 6 articles about N-{4-[4-(4-amino-3,5-dimethyl-phenyl)-1-(3,4,5-tris-tetradecyloxy-benzoyl)-piperidin-4-yl]-2,6-dimethyl-phenyl}-2,6,N-trimethyl-4-nitro-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 936027-46-2
4-(4-benzyloxycarbonylamino-3,5-dimethyl-phenyl)-4-{4-[(2,6-dimethyl-4-nitrobenzoyl)-methyl-amino]-3,5-dimethyl-phenyl}-piperidine-1-carboxylic acid benzyl ester

: 179031-22-2
3,4,5-tris(tetradecyloxy)benzoic acid

: 936027-43-9
N-{4-[4-(4-amino-3,5-dimethyl-phenyl)-1-(3,4,5-tris-tetradecyloxy-benzoyl)-piperidin-4-yl]-2,6-dimethyl-phenyl}-2,6,N-trimethyl-4-nitro-benzamide

Guidance literature:: 4-(4-benzyloxycarbonylamino-3,5-dimethyl-phenyl)-4-{4-[(2,6-dimethyl-4-nitrobenzoyl)-methyl-amino]-3,5-dimethyl-phenyl}-piperidine-1-carboxylic acid benzyl ester; With trimethylsilyl iodide; In dichloromethane;

3,4,5-tris(tetradecyloxy)benzoic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; for 16h; Further stages.;
DOI:10.1039/b617576g

Reference yield:

: 90564-17-3
2,6-dimethyl-4-nitrobenzoic acid

: 936027-43-9
N-{4-[4-(4-amino-3,5-dimethyl-phenyl)-1-(3,4,5-tris-tetradecyloxy-benzoyl)-piperidin-4-yl]-2,6-dimethyl-phenyl}-2,6,N-trimethyl-4-nitro-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl chloride / N,N-dimethylformamide / CH₂Cl₂

2.1: 90 percent / triethylamine / CHCl₃ / 144 h / Heating

3.1: Me₃SiI / CH₂Cl₂

3.2: 8 percent / triethylamine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxy-benzatriazole / CH₂Cl₂ / 16 h

With oxalyl dichloride; trimethylsilyl iodide; triethylamine; N,N-dimethyl-formamide; In dichloromethane; chloroform;
DOI:10.1039/b617576g

Reference yield:

: 936027-33-7
4-(4-amino-3,5-dimethyl-phenyl)-4-(4-benzyloxycarbonylamino-3,3-dimethyl-phenyl)-piperidine-1-carboxylic acid benzyl ester

: 936027-43-9
N-{4-[4-(4-amino-3,5-dimethyl-phenyl)-1-(3,4,5-tris-tetradecyloxy-benzoyl)-piperidin-4-yl]-2,6-dimethyl-phenyl}-2,6,N-trimethyl-4-nitro-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: aq. formaldehyde; glacial acetic acid; molecular sieves 4 Angstroem / tetrahydrofuran / 64 h

1.2: sodium cyanoborohydride / tetrahydrofuran / 7 h

1.3: 46 percent / glacial acetic acid / tetrahydrofuran / 16 h

2.1: 90 percent / triethylamine / CHCl₃ / 144 h / Heating

3.1: Me₃SiI / CH₂Cl₂

3.2: 8 percent / triethylamine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxy-benzatriazole / CH₂Cl₂ / 16 h

With formaldehyd; trimethylsilyl iodide; 4 A molecular sieve; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1039/b617576g