((2R,3S,5R)-5-(8-(3-acetylphenyl)-2-amino-6-oxo-1H-purin-9(6H)-yl)-3-(4-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-4-yl)butanoyloxy)tetrahydrofuran-2-yl)methyl 6-bromohexanoate

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Chemical Name:((2R,3S,5R)-5-(8-(3-acetylphenyl)-2-amino-6-oxo-1H-purin-9(6H)-yl)-3-(4-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-4-yl)butanoyloxy)tetrahydrofuran-2-yl)methyl 6-bromohexanoate
CAS No.:1398109-01-7
Molecular Formula:C₃₉H₃₉BrN₈O₁₀
Molecular Weight:859.69
Hs Code.:

((2R,3S,5R)-5-(8-(3-acetylphenyl)-2-amino-6-oxo-1H-purin-9(6H)-yl)-3-(4-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-4-yl)butanoyloxy)tetrahydrofuran-2-yl)methyl 6-bromohexanoate

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Chemical Property of ((2R,3S,5R)-5-(8-(3-acetylphenyl)-2-amino-6-oxo-1H-purin-9(6H)-yl)-3-(4-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-4-yl)butanoyloxy)tetrahydrofuran-2-yl)methyl 6-bromohexanoate

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Technology Process of ((2R,3S,5R)-5-(8-(3-acetylphenyl)-2-amino-6-oxo-1H-purin-9(6H)-yl)-3-(4-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-4-yl)butanoyloxy)tetrahydrofuran-2-yl)methyl 6-bromohexanoate

There total 6 articles about ((2R,3S,5R)-5-(8-(3-acetylphenyl)-2-amino-6-oxo-1H-purin-9(6H)-yl)-3-(4-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-4-yl)butanoyloxy)tetrahydrofuran-2-yl)methyl 6-bromohexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1398109-00-6
(2R,3S,5R)-5-(8-(3-acetylphenyl)-2-amino-6-oxo-1H-purin-9(6H)-yl)-2-((6-bromohexanoyloxy)methyl)tetrahydrofuran-3-yl hex-5-ynoate

: 817638-68-9
3-azido-7-hydroxycoumarin

: 1398109-01-7
((2R,3S,5R)-5-(8-(3-acetylphenyl)-2-amino-6-oxo-1H-purin-9(6H)-yl)-3-(4-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-4-yl)butanoyloxy)tetrahydrofuran-2-yl)methyl 6-bromohexanoate

Guidance literature:: With copper(II) sulphate hydrate; sodium L-ascorbate; In tetrahydrofuran; water;
DOI:10.1039/c2ob25913c

Reference yield:

: 1398108-98-9
8-(3-acetylphenyl)-2-amino-9-((2R,4S,5R)-5-((tertbutyldimethylsilyloxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-1H-purin-6(9H)-one

: 1398109-01-7
((2R,3S,5R)-5-(8-(3-acetylphenyl)-2-amino-6-oxo-1H-purin-9(6H)-yl)-3-(4-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-4-yl)butanoyloxy)tetrahydrofuran-2-yl)methyl 6-bromohexanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid; dmap / N,N-dimethyl-formamide / 1 h / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere

3.1: toluene-4-sulfonic acid; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4.1: sodium L-ascorbate; copper(II) sulphate hydrate / tetrahydrofuran; water

With dmap; copper(II) sulphate hydrate; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; sodium L-ascorbate; dicyclohexyl-carbodiimide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1039/c2ob25913c

Reference yield:

: C₂₄H₂₅N₅O₆

: 1398109-01-7
((2R,3S,5R)-5-(8-(3-acetylphenyl)-2-amino-6-oxo-1H-purin-9(6H)-yl)-3-(4-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl)-1H-1,2,3-triazol-4-yl)butanoyloxy)tetrahydrofuran-2-yl)methyl 6-bromohexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: sodium L-ascorbate; copper(II) sulphate hydrate / tetrahydrofuran; water

With copper(II) sulphate hydrate; toluene-4-sulfonic acid; sodium L-ascorbate; dicyclohexyl-carbodiimide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1039/c2ob25913c