Diethyl difluoromethylphosphonate

Base Information

• Chemical Name: Diethyl difluoromethylphosphonate
• CAS No.: 226544-67-8
• Molecular Formula: C₁₄H₂₂F₂O₅P₂
• Molecular Weight: 370.27

Synonyms:

Chemical Property of Diethyl difluoromethylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of Diethyl difluoromethylphosphonate

There total 2 articles about Diethyl difluoromethylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

Diethyl difluoromethylphosphonate (1478-53-1) + O-isopropylchloro(phenyl)phosphonate (85403-92-5) → Tetraethyl difluoromethylenediphosphonate (78715-58-9) + Isopropoxydifluoromethylphenylphosphine oxide + Diethyl difluoromethylphosphonate (226544-67-8) + Difluoromethylenebis

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; Title compound not separated from byproducts; 1.) -78 deg C, 30 min, 2.) -78 to 0 deg C;

DOI:10.1039/a900336c

Reference yield:

P,P-dichlorophenylphosphine oxide (824-72-6) → Diethyl difluoromethylphosphonate (226544-67-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 42 percent / Et₃N / toluene / 1.5 h / Ambient temperature

2: 17 percent / LDA / tetrahydrofuran / 1.) -78 deg C, 30 min, 2.) -78 to 0 deg C

With triethylamine; lithium diisopropyl amide; In tetrahydrofuran; toluene;

DOI:10.1039/a900336c

Reference yield:

Diethyl difluoromethylphosphonate (226544-67-8) → Difluoromethylphosphonic acid

Guidance literature:

With trimethylsilyl bromide; water; Yield given; Multistep reaction; 1.) r.t., 3 d, 2.) 2 h;

DOI:10.1039/a900336c

upstream raw materials:

Diethyl difluoromethylphosphonate

O-isopropylchloro(phenyl)phosphonate

P,P-dichlorophenylphosphine oxide

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