Technology Process of 2-(4-(6-methoxy-4-methylpyridin-3-yl)benzyloxy)nicotinamide
There total 4 articles about 2-(4-(6-methoxy-4-methylpyridin-3-yl)benzyloxy)nicotinamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C14H15NO2;
With
sodium hydride;
In
N,N-dimethyl-formamide; paraffin oil;
at 0 - 20 ℃;
for 0.666667h;
Inert atmosphere;
2-chloronicotinamide;
In
N,N-dimethyl-formamide; paraffin oil;
at 0 - 100 ℃;
for 2.16667h;
Inert atmosphere;
DOI:10.1021/ml4004815
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere
2.1: sodium hydride / paraffin oil; N,N-dimethyl-formamide / 0.67 h / 0 - 20 °C / Inert atmosphere
2.2: 2.17 h / 0 - 100 °C / Inert atmosphere
With
lithium aluminium tetrahydride; sodium hydride;
In
tetrahydrofuran; N,N-dimethyl-formamide; paraffin oil;
DOI:10.1021/ml4004815
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: cesium fluoride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / methanol / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere
3.1: sodium hydride / paraffin oil; N,N-dimethyl-formamide / 0.67 h / 0 - 20 °C / Inert atmosphere
3.2: 2.17 h / 0 - 100 °C / Inert atmosphere
With
lithium aluminium tetrahydride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium hydride; cesium fluoride;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide; paraffin oil;
1.1: |Suzuki Coupling;
DOI:10.1021/ml4004815
