Technology Process of C11H15FN2O
There total 4 articles about C11H15FN2O which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-fluoro-3-methylbutanoic acid; N-(tert-butoxycarbonyl)-1,4-phenylenediamine;
With
dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane;
at 20 ℃;
for 10h;
Inert atmosphere;
With
trifluoroacetic acid;
In
dichloromethane;
for 2h;
Inert atmosphere;
DOI:10.1002/ejoc.200900089
- Guidance literature:
-
Multi-step reaction with 3 steps
1: pyridine hydrogenfluoride; sodium nitrite / 3 h / -10 °C
2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 10 h / 20 °C
3: trifluoroacetic acid / dichloromethane / 2 h
With
dmap; pyridine hydrogenfluoride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; sodium nitrite;
In
dichloromethane;
DOI:10.1002/ejoc.201200147
- Guidance literature:
-
Multi-step reaction with 2 steps
1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 10 h / 20 °C
2: trifluoroacetic acid / dichloromethane / 2 h
With
dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid;
In
dichloromethane;
DOI:10.1002/ejoc.201200147